1. Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.
- Author
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Ciancanelli MJ, Huang SX, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, García-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, and Casanova JL
- Subjects
- Child, Dendritic Cells immunology, Female, Fibroblasts immunology, Genes, Recessive, Humans, Induced Pluripotent Stem Cells immunology, Influenza, Human complications, Influenza, Human genetics, Interferon Type I genetics, Leukocytes immunology, Lung immunology, Mutation, Respiratory Distress Syndrome genetics, Respiratory Distress Syndrome virology, Respiratory Mucosa immunology, Heterozygote, Influenza A Virus, H1N1 Subtype, Influenza, Human immunology, Interferon Regulatory Factor-7 genetics, Interferon Type I biosynthesis, Respiratory Distress Syndrome immunology
- Abstract
Severe influenza disease strikes otherwise healthy children and remains unexplained. We report compound heterozygous null mutations in IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy child who suffered life-threatening influenza during primary infection. In response to influenza virus, the patient's leukocytes and plasmacytoid dendritic cells produced very little type I and III interferons (IFNs). Moreover, the patient's dermal fibroblasts and induced pluripotent stem cell (iPSC)-derived pulmonary epithelial cells produced reduced amounts of type I IFN and displayed increased influenza virus replication. These findings suggest that IRF7-dependent amplification of type I and III IFNs is required for protection against primary infection by influenza virus in humans. They also show that severe influenza may result from single-gene inborn errors of immunity., (Copyright © 2015, American Association for the Advancement of Science.)
- Published
- 2015
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