1. ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment.
- Author
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Heyman, Jefri, Cools, Toon, Vandenbussche, Filip, Heyndrickx, Ken S., Van Leene, Jelle, Vercauteren, Ilse, Vanderauwera, Sandy, Vandepoele, Klaas, De Jaeger, Geert, Van Der Straeten, Dominique, and De Veylder, Lieven
- Subjects
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CELL division , *CELL cycle , *PROTEOLYSIS , *TRANSCRIPTION factors , *STEM cell transplantation , *GENE expression , *PEPTIDE hormones , *BRASSINOSTEROIDS - Abstract
The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/CCCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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