1. Detection and localization of surgically resectable cancers with a multi-analyte blood test
- Author
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Lisa Dobbyn, Joshua T. Vogelstein, Tian Li Wang, Ammar A. Javed, Robert E. Schoen, Ralph H. Hruban, Nickolas Papadopoulos, Chetan Bettegowda, Michael Goggins, Natalie Silliman, Janine Ptak, Peter J. Allen, Bert Vogelstein, Cristian Tomasetti, Austin Mattox, Joy Schaefer, Yuxuan Wang, Kenneth W. Kinzler, Bahman Afsari, Lu Li, Christopher L. Wolfgang, Richard B.S. Roden, Anne Marie Lennon, Hui-Li Wong, J.D. Browne, Peter Gibbs, Marco Dal Molin, Jeanne Tie, Alison P. Klein, Shibin Zhou, Aaron S. Mansfield, Jin Jen, Luis A. Diaz, Randall E. Brand, Samir M. Hanash, Massimo Falconi, Christopher Douville, Ludmila Danilova, Maria Popoli, Christopher J. Thoburn, Fay Wong, Joshua D. Cohen, Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C. L., Goggins, M. G., Molin, M. D., Wang, T. -L., Roden, R., Klein, A. P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. -L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Lennon, A. M., and Papadopoulos, N.
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0301 basic medicine ,medicine.medical_specialty ,Health Knowledge, Attitudes, Practice ,Ovary ,Gastroenterology ,Polymerase Chain Reaction ,Article ,Circulating Tumor DNA ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Neoplasms ,Medicine ,Blood test ,Humans ,Esophagus ,Lung cancer ,Early Detection of Cancer ,Multidisciplinary ,Lung ,Hematologic Tests ,medicine.diagnostic_test ,business.industry ,Stomach ,Cancer ,medicine.disease ,Neoplasm Proteins ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Mutation ,Costs and Cost Analysis ,business ,Pancreas - Abstract
SEEK and you may find cancer earlier Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity. Science , this issue p. 926 ; see also p. 866
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- 2018