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Your search keyword '"Karp, Philip H."' showing total 4 results
Start Over Author "Karp, Philip H." Publisher american association for the advancement of science
4 results on '"Karp, Philip H."'

1. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

Author

Rogers, Christopher S., Stoltz, David A., Meyerholz, David K., Ostedgaard, Lynda S., Rokhlina, Tatiana, Taft, Peter J., Rogan, Mark P., Pezzulo, Alejandro A., Karp, Philip H., Itani, Omar A., Kabel, Amanda C., Wohlford-Lenane, Christine L., Davis, Greg J., Hanfland, Robert A., Smith, Tony L., Samuel, Melissa, Wax, David, Murphy, Clifton N., Rieke, August, Whitworth, Kristin, Uc, Aliye, Starner, Timothy D., Brogden, Kim A., Shilyansky, Joel, McCray, Paul B., Jr., Zabner, Joseph, Prather, Randall S., and Welsh, Michael J.

Subjects
Cystic fibrosis -- Models, Cystic fibrosis -- Genetic aspects
Published
2008

2. The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs.

Author

Ostedgaard, Lynda S., Meyerholz, David K., Chen, Jeng-Haur, Pezzulo, Alejandro A., Karp, Philip H., Rokhlina, Tatiana, Ernst, Sarah E., Hanfland, Robert A., Reznikov, Leah R., Ludwig, Paula S., Rogan, Mark P., Davis, Greg J., Dohrn, Cassie L., Wohlford-Lenane, Christine, Taft, Peter J., Rector, Michael V., Hornick, Emma, Nassar, Boulos S., Samuel, Melissa, and Zhang, Yuping

Published
2011
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3. Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth.

Author

Stoltz, David A., Meyerholz, David K., Pezzulo, Alejandro A., Ramachandran, Shyam, Rogan, Mark P., Davis, Greg J., Hanfland, Robert A., Wohlford-Lenane, Chris, Dohrn, Cassie L., Bartlett, Jennifer A., Nelson IV, George A., Chang, Eugene H., Taft, Peter J., Ludwig, Paula S., Estin, Mira, Hornick, Emma E., Launspach, Janice L., Samue, Melissa, Rokhlina, Tatiana, and Karp, Philip H.

Published
2010
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4. Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

Author

Shah, Viral S., Meyerholz, David K., Xiao Xiao Tang, Reznikov, Leah, Alaiwa, Mahmoud Abou, Ernst, Sarah E., Karp, Philip H., Wohlford-Lenane, Christine L., Heilmann, Kristopher P., Leidinger, Mariah R., Allen, Patrick D., Zabner, Joseph, McCray Jr, Paul B., Ostedgaard, Lynda S., Stoltz, David A., Randak, Christoph O., and Welsh, Michael J.

Subjects
*ACIDIFICATION, *CYSTIC fibrosis, *LABORATORY mice, *BICARBONATE ions, *GENETIC mutation
Abstract

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss of CFTR impairs respiratory host defenses, causing airway infection. But CF mice are spared. We found that in all three species, CFTR secreted bicarbonate into airway surface liquid. In humans and pigs lacking CFTR, unchecked H+ secretion by the nongastric H+/K+ adenosine triphosphatase (ATP12A) acidified airway surface liquid, which impaired airway host defenses. In contrast, mouse airways expressed little ATP12A and secreted minimal H+; consequently, airway surface liquid in CF and non-CF mice had similar pH. Inhibiting ATP12A reversed host defense abnormalities in human and pig airways. Conversely, expressing ATP12A in CF mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria. These findings help explain why CF mice are protected from infection and nominate ATP12A as a potential therapeutic target for CF. [ABSTRACT FROM AUTHOR]

Published
2016
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