1. Immunohistochemistry of adenosine deaminase: implications for adenosine neurotransmission.
- Author
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Nagy JI, LaBella LA, Buss M, and Daddona PE
- Subjects
- Animals, Brain enzymology, Hypothalamus enzymology, Immunochemistry, Neurons enzymology, Rats, Receptors, Cell Surface metabolism, Receptors, Purinergic, Septal Nuclei enzymology, Superior Colliculi enzymology, Adenosine physiology, Adenosine Deaminase immunology, Neurotransmitter Agents physiology, Nucleoside Deaminases immunology
- Abstract
Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Most other brain regions were devoid of cells containing adenosine deaminase. Some adenosine deaminase-containing neurons were retrogradely labeled with the fluorescent dye fast blue when the dye was injected into the frontal cortex and striatum. Specific populations of neurons having high levels of adenosine deaminase may release adenosine as a neurotransmitter.
- Published
- 1984
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