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Your search keyword '"Oleksyk TK"' showing total 3 results
Start Over Author "Oleksyk TK" Publisher american association for the advancement of science
3 results on '"Oleksyk TK"'

1. Remote opportunities for scholars in Ukraine.

Author

Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj PP, Romero V, Hlávka J, Oleksyk TK, and Mangul S

Published
2022
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3. Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

Author

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, and Pollak MR

Subjects
Africa, Alleles, Apolipoprotein L1, Apolipoproteins blood, Apolipoproteins metabolism, Case-Control Studies, Cohort Studies, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Glomerulosclerosis, Focal Segmental ethnology, Haplotypes, Humans, Hypertension complications, Immunity, Innate, Kidney Failure, Chronic ethnology, Kidney Failure, Chronic etiology, Linkage Disequilibrium, Lipoproteins, HDL blood, Lipoproteins, HDL metabolism, Logistic Models, Molecular Motor Proteins genetics, Myosin Heavy Chains genetics, Recombinant Proteins metabolism, Selection, Genetic, Sequence Deletion, Trypanosomiasis, African genetics, Trypanosomiasis, African parasitology, Black or African American genetics, Apolipoproteins genetics, Glomerulosclerosis, Focal Segmental genetics, Kidney Failure, Chronic genetics, Lipoproteins, HDL genetics, Polymorphism, Single Nucleotide, Trypanosoma brucei rhodesiense metabolism
Abstract

African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD odds ratio = 7.3 (95% CI 5.6 to 9.5)}. The two APOL1 variants are common in African chromosomes but absent from European chromosomes, and both reside within haplotypes that harbor signatures of positive selection. ApoL1 (apolipoprotein L-1) is a serum factor that lyses trypanosomes. In vitro assays revealed that only the kidney disease-associated ApoL1 variants lysed Trypanosoma brucei rhodesiense. We speculate that evolution of a critical survival factor in Africa may have contributed to the high rates of renal disease in African Americans.

Published
2010
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