1. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
- Author
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Dent, Alexander L., Shaffer, Arthur L., Yu, Xin, Allman, David, and Staudt, Louis M.
- Subjects
Lymphomas -- Genetic aspects -- Research ,Cellular signal transduction -- Research -- Genetic aspects ,Science and technology ,Genetic aspects ,Research - Abstract
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)-induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies., Diffuse large cell Iymphoma is a common and aggressive subtype of B cell nonHodgkin's Iymphoma that frequently harbors genetic alterations in the BCL-6 gene: Up to 45% of these lymphomas [...]
- Published
- 1997