1. Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress.
- Author
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Condic N, Amiji H, Patel D, Shropshire WC, Lermi NO, Sabha Y, John B, Hanson B, and Karras GI
- Subjects
- Beer, Bread, Gene Duplication, Metabolic Networks and Pathways genetics, Protein Folding, Stress, Physiological genetics, Adaptation, Physiological genetics, Ethanol metabolism, HSP90 Heat-Shock Proteins metabolism, HSP90 Heat-Shock Proteins genetics, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins metabolism, Saccharomyces cerevisiae Proteins genetics, Selection, Genetic, Fermentation genetics
- Abstract
Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of beer and bread domestication. This work demonstrates a mechanism of adaptive canalization in an ecology of major economic importance and highlights Hsp90-dependent variation as an important source of phantom heritability in complex traits.
- Published
- 2024
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