1. All major cholesterol-dependent cytolysins use glycans as cellular receptors.
- Author
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Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Zhenyao Luo, Kobe, Bostjan, Nizet, Victor, Itzstein, Mark von, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J., and Jennings, Michael P.
- Subjects
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IMMOBILIZED cells , *MEDICAL sciences , *BLOOD group antigens , *BLOOD groups , *INTEGRINS , *CHO cell , *CELL receptors , *ERYTHROCYTES - Abstract
The article presents a study related to all major cholesterol-dependent cytolysins that use glycans as cellular receptors. It mentions that CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors; and also mentions that Streptolysin O, vaginolysin, and perfringolysin O bind multiple glycans, and pneumolysin, lectinolysin, and listeriolysin O recognize a single glycan class.
- Published
- 2020
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