1. Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
- Author
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Kerstin B. Kaufmann, Elisa Laurenti, Sasan Zandi, Naoya Takayama, Stephanie M. Dobson, Faiyaz Notta, Cyrille F. Dunant, John Douglas Mcpherson, Lincoln Stein, Jessica McLeod, Olga I. Gan, Gavin W. Wilson, Yigal Dror, and John E. Dick
- Subjects
0301 basic medicine ,Genetics ,Multidisciplinary ,Myeloid ,Megakaryocyte Progenitor Cells ,Biology ,3. Good health ,Cell biology ,Blood cell ,03 medical and health sciences ,Haematopoiesis ,030104 developmental biology ,medicine.anatomical_structure ,Multipotent Stem Cell ,medicine ,Bone marrow ,Progenitor cell ,Progenitor - Abstract
Adjusting hematopoietic hierarchy In adults, more than 300 billion blood cells are replenished daily. This output arises from a cellular hierarchy where stem cells differentiate into a series of multilineage progenitors, culminating in unilineage progenitors that generate over 10 different mature blood cell types. Notta et al. mapped the lineage potential of nearly 3000 single cells from 33 different cell populations of stem and progenitor cells from fetal liver, cord blood, and adult bone marrow (see the Perspective by Cabezas-Wallscheid and Trumpp). Prenatally, stem cell and progenitor populations were multilineage with few unilineage progenitors. In adults, multilineage cell potential was only seen in stem cell populations. Science , this issue p. 10.1126/science.aab2116 ; see also p. 126
- Published
- 2016
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