1. Structural basis for integration of GluD receptors within synaptic organizer complexes
- Author
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Michisuke Yuzaki, Eriko Miura, Nikolaos Mitakidis, Terunaga Nakagawa, Ingo H. Greger, A. Radu Aricescu, Natalie F. Shanks, Christian Siebold, Junko Motohashi, Ester Behiels, Wataru Kakegawa, Veronica T. Chang, Maxim Rossmann, Kazuhisa Kohda, Jordan E. Clay, Keiko Matsuda, and Jonathan Elegheert
- Subjects
0301 basic medicine ,Neurogenesis ,Synaptogenesis ,GLUD2 ,Nerve Tissue Proteins ,Biology ,Ligands ,Article ,Mice ,Purkinje Cells ,03 medical and health sciences ,Protein structure ,Postsynaptic potential ,Animals ,Protein Precursors ,Long-Term Synaptic Depression ,Multidisciplinary ,Anatomy ,Protein Structure, Tertiary ,030104 developmental biology ,Receptors, Glutamate ,Synapses ,Excitatory postsynaptic potential ,Ionotropic glutamate receptor ,Protein Multimerization ,Signal transduction ,Neuroscience ,Signal Transduction - Abstract
Transmitting signals across the synapse Glutamate receptors located on neuronal cells play a role in mediating electrical signals at excitatory synapses. These glutamatergic synapses are extremely important for nearly all cognitive functions. Elegheert et al. analyzed a complex that bridges the synapse, comprising β-neurexin 1, a cell adhesion molecule on the surface of presynaptic axons; cerebellin 1, a synaptic organizer; and the postsynaptic glutamate receptor GluD2. The structural and functional analysis provides insight into the mechanism of synaptic signaling. Science , this issue p. 295
- Published
- 2016
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