Search

Your search keyword '"Steiner TM"' showing total 2 results
Start Over Author "Steiner TM" Publisher american association of immunologists
2 results on '"Steiner TM"'

1. Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.

Author

Kato, Y, Steiner, TM, Park, H-Y, Hitchcock, RO, Zaid, A, Hor, JL, Devi, S, Davey, GM, Vremec, D, Tullett, KM, Tan, PS, Ahmet, F, Mueller, SN, Alonso, S, Tarlinton, DM, Ploegh, HL, Kaisho, T, Beattie, L, Manton, JH, Fernandez-Ruiz, D, Shortman, K, Lahoud, MH, Heath, WR, Caminschi, I, Kato, Y, Steiner, TM, Park, H-Y, Hitchcock, RO, Zaid, A, Hor, JL, Devi, S, Davey, GM, Vremec, D, Tullett, KM, Tan, PS, Ahmet, F, Mueller, SN, Alonso, S, Tarlinton, DM, Ploegh, HL, Kaisho, T, Beattie, L, Manton, JH, Fernandez-Ruiz, D, Shortman, K, Lahoud, MH, Heath, WR, and Caminschi, I

Abstract

Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine cDC1 interact extensively with B cells at the border of B cell follicles and, when Ag is targeted to Clec9A, can display native Ag for B cell activation. This leads to efficient induction of humoral immunity. Our findings indicate that surface display of native Ag on cDC with access to both T and B cells is key to efficient humoral vaccination.

Published
2020

2. Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.

Author

Kato Y, Steiner TM, Park HY, Hitchcock RO, Zaid A, Hor JL, Devi S, Davey GM, Vremec D, Tullett KM, Tan PS, Ahmet F, Mueller SN, Alonso S, Tarlinton DM, Ploegh HL, Kaisho T, Beattie L, Manton JH, Fernandez-Ruiz D, Shortman K, Lahoud MH, Heath WR, and Caminschi I

Subjects
Animals, Antigen Presentation, Autoantigens immunology, Autoantigens metabolism, Cell Differentiation, Cells, Cultured, Cytokines metabolism, Immunity, Humoral, Lectins, C-Type genetics, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Immunologic genetics, Vaccination, B-Lymphocytes immunology, Dendritic Cells immunology, Lectins, C-Type metabolism, Receptors, Immunologic metabolism, Th1 Cells immunology, Th2 Cells immunology
Abstract

Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine cDC1 interact extensively with B cells at the border of B cell follicles and, when Ag is targeted to Clec9A, can display native Ag for B cell activation. This leads to efficient induction of humoral immunity. Our findings indicate that surface display of native Ag on cDC with access to both T and B cells is key to efficient humoral vaccination., (Copyright © 2020 by The American Association of Immunologists, Inc.)

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results