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1. Novel Cyclic Hexapeptides from Marine-Derived Fungus, Aspergillus sclerotiorumPT06-1.

Author

Jinkai Zheng, Huajie Zhu, Kui Hong, Yi Wang, Peipei Liu, Xin Wang, Xiaoping Peng, and Weiming Zhu

Subjects
*ORGANIC cyclic compounds, *AMINOBENZOIC acids, *RADICALS (Chemistry), *CHEMICAL reactions, *PHOTOISOMERIZATION, *ANTIFUNGAL agents, *CELL-mediated cytotoxicity
Abstract

Two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino acid units, sclerotides A (1) and B (2), were isolated from the marine-derived halotolerant Aspergillus sclerotiorumPT06-1 in a nutrient-limited hypersaline medium. Both 1and 2are photointerconvertible and could be interconverted via a radical reaction initiated by direct photoisomerization. Both compounds showed moderate antifungal activity. Compound 2also showed weak cytotoxicity and antibacterial activity. [ABSTRACT FROM AUTHOR]

Published
2009
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