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1. Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes.

Author

Makaravage, Katarina J., Xia Shao, Brooks, Allen F., Lingyun Yang, Sanford, Melanie S., and Scott, Peter J. H.

Subjects
*COPPER compounds, *BORONIC acids, *STANNANE, *BORON compounds, *CHEMICAL yield
Abstract

A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [11C]perampanel in 10% nondecay-corrected radiochemical yield (RCY). [ABSTRACT FROM AUTHOR]

Published
2018
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