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Your search keyword '"Scott, Peter"' showing total 2 results
Start Over Author "Scott, Peter" Topic boronic acids Publisher american chemical society
2 results on '"Scott, Peter"'

1. Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes.

Author

Makaravage, Katarina J., Xia Shao, Brooks, Allen F., Lingyun Yang, Sanford, Melanie S., and Scott, Peter J. H.

Subjects
*COPPER compounds, *BORONIC acids, *STANNANE, *BORON compounds, *CHEMICAL yield
Abstract

A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [11C]perampanel in 10% nondecay-corrected radiochemical yield (RCY). [ABSTRACT FROM AUTHOR]

Published
2018
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2. Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.

Author

Mossine, Andrew V., Brooks, Allen F., Makaravage, Katarina J., Miller, Jason M., Naoko Ichiishi, Sanford, Melanie S., and Scott, Peter J. H.

Subjects
*AROMATIC compound synthesis, *COPPER compounds, *FLUORINATION, *BORONIC acids, *GLUTAMATE receptors
Abstract

A copper-mediated radiofluorination of aryl- and vinylboronic acids with K18F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [18F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors. [ABSTRACT FROM AUTHOR]

Published
2015
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