Search

The world needs sustainable energy resources with affordable, economic, and accountable sources. Consequently, energy innovation technologies are evolving toward electrochemical applications like batteries, supercapacitors, etc. The current study involves the solid blend biopolymer electrolyte (SBBE) with different compositions of sodium alginate blended with pectin via the casting technique. The characterization of the sample was tested by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, AC impedance, linear sweep voltammetry (LSV), and cyclic voltammetry (CV) analyses. Evidently, the sample NP4 (NaAlg/pectin = 60:40 wt %) has a higher conductivity of 1.26 × 10 -7 and 3.25 × 10 -6 S cm -1 at 303 and 353 K, respectively. The performances of the samples were analyzed with variations in temperature, frequency, and time responses to signify the blended nature of the electrolyte. Hence, the studied biopolymers can be constructed for electrochemical device applications., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Colorectal carcinogenesis is a complex process, which is linked to dysregulation of human secretory phospholipases A 2 (hsPLA 2 -G-IIA, hsPLA 2 -G- V , and hsPLA 2 -G- X) , proteases (cathepsin-B, collagenase, thrombin, elastase, and trypsin), carbohydrate hydrolyzing enzymes (α-amylase and α-glucosidase), and free radical generating enzyme (xanthine oxidoreductase (XOR)). Therefore, some new quinazolinones were synthesized and evaluated as inhibitors against this array of enzymes as well as cytotoxic agents on LoVo and HCT-116 cells of colorectal cancer. Compounds 3g , 10 , 8 , 3c , and 1c exhibited promising cytotoxic effects with IC 50 values ranging from 206.07 to 459.79 μM. Nine compounds showed promising enzymatic inhibitory effects, 3b , 3d , 3f , 5 , 1a , and 12 (α-amylase), 8 (thrombin, elastase and trypsin), 10 (hsPLA 2 -G-IIA and hsPLA 2 -G-V), and 3f (α-glucosidase and XOR). Therefore, the most active inhibitors, were subjected to validated molecular docking studies to identify their affinities and binding modes. The expected physicochemical and pharmacokinetic features of the active candidates, 1a , 1c , 3b , 3c , 3d , 3f , 3g , 5 , 8 , 10 , and 12 were predicted using bioavailability radar charts and boiled-egg graphical representations along with the Lipinski rule of five filter. Collectively, these studies showed the significance of derivatives 1c , 3b , 3c , 3d , 8 , 10 , and 12 as lead scaffolds for further optimization to develop enzymes inhibitors and anti-colorectal agents., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)

1,4-Dihydropyridines (1,4-DHPs) hold a top-notch position in the pharmaceutical world due to a broader spectrum of applications, whereas the carboxylic moiety has been an integral part of the physiological world, effective food preservatives, and antimicrobial agents. Seeking the enormous potential and applications of these two classes, we worked to combine these to synthesize 2,2'-[3,5-bis(ethoxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]diacetic acid the novel dicarboxylic derivatives of 1,4-DHP ( 9a - k ) achieved via the electro-carboxylation of tetrasubstituted-1,4-dihydropyridines ( 8a - k ) derivatives using Mg-Pt electrodes in an undivided cell. The targeted compounds were established by 1 H, 13 C NMR, IR, and ESI-MS. Further, the synthesized compounds show excellent resistance against various microbes and the activity increased 2-3 folds after the introduction of acid groups. Compound 9b (against E. coli , S. aureus , B. subtilis , A. niger , and P. glabrum ), 9d (against E. coli , K. pneumonia , S. aureus , A. janus , and F. oxysporum) , 9f (against E. coli and P. fluorescens ), and 9k (against F. oxysporum and P. glabrum) were found to be highly active at 4 μg/mL with reference to standard amoxicillin and fluconazole. Further, the present synthetic protocol would open new gates for other researchers to develop new molecules by bioisosteres of these substrates., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)