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Start Over Author "Ashton, Alun" Publisher american chemical society
1 results on '"Ashton, Alun"'

1. The solution structure of human coagulation factor VIIa in its complex with tissue factor is similar to free factor VIIa: a study of a heterodimeric receptor-ligand complex by x-ray and neutron scattering and computational modeling

Author

Ashton, Alun W., Boehm, Mark K., Johnson, Daniel J.D., Kemball-Cook, Geoffrey, and Perkins, Stephen J.

Subjects
Blood coagulation factors -- Analysis, Binding sites (Biochemistry) -- Analysis, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

The structure of the heterodimeric receptor-ligand complex found in human coagulation factor VIIa (FVIIa) has been studied using x-ray and neutron scattering. FVIIa is a soluble four-domain plasma serine protease that binds with the two extracellular domains of the transmembrane tissue factor during blood coagulation. The study gives insight on the domain structure of free FVIIa in solution to illustrate how membrane-bound tissue factors detect the FVIIa as a ligand.

Published
1998

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