1. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
- Author
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Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, and Shapiro TA
- Subjects
- Animals, Antimalarials chemistry, Antimalarials therapeutic use, Artemisinins chemistry, Artemisinins therapeutic use, Bridged Bicyclo Compounds, Heterocyclic chemistry, Bridged Bicyclo Compounds, Heterocyclic therapeutic use, Malaria mortality, Mice, Plasmodium berghei, Structure-Activity Relationship, Antimalarials chemical synthesis, Artemisinins chemical synthesis, Bridged Bicyclo Compounds, Heterocyclic chemical synthesis, Malaria drug therapy
- Abstract
We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.
- Published
- 2007
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