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Your search keyword '"Chen, Chih-Lin"' showing total 5 results
Start Over Author "Chen, Chih-Lin" Publisher american chemical society
5 results on '"Chen, Chih-Lin"'

3. Chemical Reaction Engineering—Boston

Author

James Wei, Christos Georgakis, D. ARNTZ, K. KNAPP, G. PRESCHER, G. EMIG, H. HOFMANN, A. BAIKER, M. BERGOUGNAN, W. RICHARZ, R. HUGHES, E. K. T. KAM, W.-K. LIAW, J. VILLADSEN, R. JACKSON, D. VORTMEYER, R. P. WINTER, VEMURI BALAKOTAIAH, DAN LUSS, A. E. ELHADERI, T. T. TSOTSIS, V. HLAVACEK, J. PUSZYNSKI, P. VAN ROMPAY, A. K. JAIN, P. L. SILVESTON, R. R. HUDGINS, L. S. KERSHENBAUM, F. LOPEZ-ISUNZA, WERNER BAUER, JOACHIM WERTHER, GERHART EIGENBERGER, ULRIKE WEGERLE, J. MANKIN, P. LAMBA, J. L. HUDSON, GREGORY STEPHANOPOULOS, KA-YIU SAN, MICHAEL STOUKIDES, SAVVAS SEIMANIDES, COSTAS VAYENAS, J. C. DE DEKEN, E. F. DEVOS, G. F. FROMENT, E. PH. KIEFFER, H. S. VAN DER BAAN, MASAYOSHI KOBAYASHI, CHARLES N. SATTERFIELD, GEORGE A. HUFF, AKINORI YOKOYAMA, HIROSHI KOMIYAMA, HAKUAI INOUE, TSUYOSHI MASUMOTO, HISAMICHI KIMURA, CHEN-CHIH LIN, WILLIAM J. HATCHER, C. W. NUTT, S. KAPUR, A. MAJEED, DEEPAK PERTI, ROBERT L. KABEL, S. R. POOKOTE, J. S. DRANOFF, J. B. BUTT, ALAN W. WARDWELL, ROBERT W. CARR, RUTHERFORD ARIS, HONG JU CHANG, MAYIS SEAPAN, BILLY L. CRYNES, HENRY W. HAYNE, James Wei, Christos Georgakis, D. ARNTZ, K. KNAPP, G. PRESCHER, G. EMIG, H. HOFMANN, A. BAIKER, M. BERGOUGNAN, W. RICHARZ, R. HUGHES, E. K. T. KAM, W.-K. LIAW, J. VILLADSEN, R. JACKSON, D. VORTMEYER, R. P. WINTER, VEMURI BALAKOTAIAH, DAN LUSS, A. E. ELHADERI, T. T. TSOTSIS, V. HLAVACEK, J. PUSZYNSKI, P. VAN ROMPAY, A. K. JAIN, P. L. SILVESTON, R. R. HUDGINS, L. S. KERSHENBAUM, F. LOPEZ-ISUNZA, WERNER BAUER, JOACHIM WERTHER, GERHART EIGENBERGER, ULRIKE WEGERLE, J. MANKIN, P. LAMBA, J. L. HUDSON, GREGORY STEPHANOPOULOS, KA-YIU SAN, MICHAEL STOUKIDES, SAVVAS SEIMANIDES, COSTAS VAYENAS, J. C. DE DEKEN, E. F. DEVOS, G. F. FROMENT, E. PH. KIEFFER, H. S. VAN DER BAAN, MASAYOSHI KOBAYASHI, CHARLES N. SATTERFIELD, GEORGE A. HUFF, AKINORI YOKOYAMA, HIROSHI KOMIYAMA, HAKUAI INOUE, TSUYOSHI MASUMOTO, HISAMICHI KIMURA, CHEN-CHIH LIN, WILLIAM J. HATCHER, C. W. NUTT, S. KAPUR, A. MAJEED, DEEPAK PERTI, ROBERT L. KABEL, S. R. POOKOTE, J. S. DRANOFF, J. B. BUTT, ALAN W. WARDWELL, ROBERT W. CARR, RUTHERFORD ARIS, HONG JU CHANG, MAYIS SEAPAN, BILLY L. CRYNES, and HENRY W. HAYNE

Subjects
Chemical engineering--Congresses, Chemical reactors--Congresses
Published
1982

4. Predicting Breast Cancer by Paper Spray Ion Mobility Spectrometry Mass Spectrometry and Machine Learning.

Author

Huang YC, Chung HH, Dutkiewicz EP, Chen CL, Hsieh HY, Chen BR, Wang MY, and Hsu CC

Subjects
Algorithms, Female, Humans, Ion Mobility Spectrometry, Spectrometry, Mass, Electrospray Ionization, Breast Neoplasms diagnosis, Machine Learning, Paper
Abstract

Paper spray ionization has been used as a fast sampling/ionization method for the direct mass spectrometric analysis of biological samples at ambient conditions. Here, we demonstrated that by utilizing paper spray ionization-mass spectrometry (PSI-MS) coupled with field asymmetric waveform ion mobility spectrometry (FAIMS), predictive metabolic and lipidomic profiles of routine breast core needle biopsies could be obtained effectively. By the combination of machine learning algorithms and pathological examination reports, we developed a classification model, which has an overall accuracy of 87.5% for an instantaneous differentiation between cancerous and noncancerous breast tissues utilizing metabolic and lipidomic profiles. Our results suggested that paper spray ionization-ion mobility spectrometry-mass spectrometry (PSI-IMS-MS) is a powerful approach for rapid breast cancer diagnosis based on altered metabolic and lipidomic profiles.

Published
2020
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5. Nucleotide-Dependent Bioautocatalytic Timer Reaction.

Author

Chen TR, Hsu CF, Chen CL, Witek HA, and Urban PL

Subjects
Bioengineering methods, Catalysis, Kinetics, Luminescence, Adenosine Diphosphate metabolism, Adenosine Monophosphate metabolism, Adenosine Triphosphate metabolism
Abstract

We describe a biochemical timer composed of three biocatalytic reactions involving three types of adenylate nucleotides: adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP). The timer is triggered by a small amount of ATP or ADP. An abrupt increase in the ATP concentration (following numerous amplification cycles) leads to a sudden increase of luminescence from the reaction mixture. The time point when the luminescence appears is found to be a function of the initial concentration of the triggering nucleotide (5.0 × 10(-8)-1.0 × 10(-6) M), even in the presence of a complex biological matrix. The mechanism of the observed dependence of the time of luminescence increase on the concentration has been confirmed with simple kinetic models. Due to the biocompatibility of the proposed trienzymatic reaction scheme (sensitivity to common nucleotides and occurrence in a neutral pH aqueous environment), the scheme can be used in bioengineered systems that require modulation of the response time (light emission) by concentration.

Published
2016
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