Search

Your search keyword '"Chihiro Tsukano"' showing total 4 results
Start Over Author "Chihiro Tsukano" Publisher american chemical society
4 results on '"Chihiro Tsukano"'

1. Synthesis of Octahydro- and Decahydroquinolines by a One-Pot Cascade Reaction of Tetrasubstituted Enecarbamate

Author

Yoshiji Takemoto, Chihiro Tsukano, and Tomohiro Kurose

Subjects
010405 organic chemistry, Chemistry, Cyclopropanation, Organic Chemistry, Iminium, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Biochemistry, 0104 chemical sciences, Cyclopropane, chemistry.chemical_compound, Cascade reaction, Organic chemistry, Physical and Theoretical Chemistry, Quaternary carbon
Abstract

A transition-metal-catalyzed cyclopropanation followed by ring opening was investigated for the synthesis of octahydroquinolines 4 and decahydroquinolines 5 having a quaternary carbon center at the angular position, which are core structures of the fawcettimine-type alkaloids. A tandem reaction was also established for the synthesis of decahydroquinolines 5 and the tricyclic compound 6 through an iminium ion intermediate, readily produced by acidic treatment of cyclopropane 2.

Published
2017

2. Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Author

Hugh Nakamura, Takuma Yoshida, Yoshiji Takemoto, and Chihiro Tsukano

Subjects
010405 organic chemistry, Organic Chemistry, Chemical modification, Core (manufacturing), 010402 general chemistry, 01 natural sciences, Biochemistry, Uridine, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Amide, Intramolecular force, Polymer chemistry, Vinyl iodide, Organic chemistry, Physical and Theoretical Chemistry
Abstract

CPZEN-45 was developed as an antibiotic against Mycobacterium tuberculosis by the chemical modification of caprazamycins. CPZEN-45 has been synthesized in this study by the Cu-catalyzed intramolecular amidation of a complex vinyl iodide precursor bearing uridine and sugar moieties with a secondary amide, allowing for the construction of its 1, 4-diazepin-2-one core.

Published
2016

3. Synthesis of Octahydro- and Decahydroquinolines by a One-Pot Cascade Reaction of Tetrasubstituted Enecarbamate.

Author

Tomohiro Kurose, Chihiro Tsukano, and Yoshiji Takemoto

Subjects
*AROMATIC compound synthesis, *TRANSITION metal catalysts, *CYCLOPROPANATION, *CARBAMATES, *CHEMICAL reactions
Abstract

A transition-metal-catalyzed cyclopropanation followed by ring opening was investigated for the synthesis of octahydroquinolines 4 and decahydroquinolines 5 having a quaternary carbon center at the angular position, which are core structures of the fawcettimine-type alkaloids. A tandem reaction was also established for the synthesis of decahydroquinolines 5 and the tricyclic compound 6 through an iminium ion intermediate, readily produced by acidic treatment of cyclopropane 2. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results