13 results on '"Frutos, Rogelio P."'
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2. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation.
3. Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin).
4. Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling.
5. Stereoselective synthesis of 1-aryl-4a-methyloctahydrophenanthrenes via cyclization reactions initiated by benzylic cations
6. Intramolecular formal /3 + 2~ cycloaddition of alkenes and benzylic cations: stereoselective synthesis of 1,2,3,4,4a,9a-hexahydrofluorenes
7. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.
8. Asymmetric Oxidation of a Dihydrothienopyrimidine.
9. Development of a Practical Process for the Synthesis of PDE4 Inhibitors.
10. Development of a Safe and Economical Synthesis ofMethyl 6-Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylationon Kilogram Scale.
11. One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles.
12. Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis.
13. Intramolecular formal[3+2] cycloaddition of alkenes and benzylic cations. Stereoselective...
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