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Start Over Author "Furuta, Miho" Publisher american chemical society
1 results on '"Furuta, Miho"'

1. Novel phenalenone derivatives from a marine-derived fungus exhibit distinct inhibition spectra against eukaryotic DNA polymerases

Author

Perpelescu, Marinela, Kobayashi, Jun'ichi, Furuta, Miho, Ito, Yasutomo, Izuta, Shunji, Takemura, Masaharu, Suzuki, Motoshi, and Yoshida, Shonen

Subjects
DNA polymerases -- Analysis, Enzyme inhibitors -- Analysis, Electric charge and distribution -- Influence, Mechanical chemistry -- Research, Biological sciences, Chemistry
Abstract

Research elucidates the mechanism of inhibition of DNA polymerase by two phenalenone derivatives from marine-derived fungus. Results show that sculezonone-B selectively inhibits DNA pol alpha and gamma, whereas sculezonone-A inhibits pol beta. Data suggest that the different inhibition spectra is due to differences in the distribution of electrostatic potential on their molecular surfaces.

Published
2002

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