Search

Your search keyword '"Jacek Lipkowski"' showing total 15 results
Start Over Author "Jacek Lipkowski" Publisher american chemical society
15 results on '"Jacek Lipkowski"'

15. Electrochemical and PM-IRRAS Studies of the Effect of Cholesterol on the Properties of the Headgroup Region of a DMPC Bilayer Supported at a Au(111) Electrode.

Author

Xiaomin Bin and Jacek Lipkowski

Subjects
*CHOLESTEROL, *GOLD, *ELECTRODES, *SPECTRUM analysis
Abstract

Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) was employed to investigate the interaction of cholesterol with the headgroups of dimyristoylphosphatidycholine (DMPC) molecules under a static electric field. DMPC/cholesterol (7:3 molar ratio) mixtures form a bilayer on a Au(111) electrode surface by fusion and spreading of small unilamellar vesicles. PM-IRRAS experiments provided detailed information concerning the conformation and hydration of headgroups of DMPC bilayers in the presence and absence of 30% cholesterol. The presence of 30% cholesterol increases the space between the headgroups of DMPC molecules and hence increases the hydration of the DMPC/cholesterol mixed bilayer. The conformational state of the headgroups of DMPC molecules in the mixed bilayer is also significantly changed. The phosphate group is closer to the surface compared with the pure DMPC bilayer. The conformation of the -O-C-C-N moiety changes from gauche to trans in the presence of cholesterol. [ABSTRACT FROM AUTHOR]

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results