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Your search keyword '"Jiqing Jiang"' showing total 2 results
Start Over Author "Jiqing Jiang" Publisher american chemical society
2 results on '"Jiqing Jiang"'

1. Aromatic nucleophilic substitution or CuI-catalyzed coupling route to martinellic acid

Author

Dawei Ma, Chengfeng Xia, Jiqing Jiang, Jianhua Zhang, and Wenjun Tang

Subjects
Chemistry, Organic -- Research, Acids -- Composition, Substitution reactions -- Analysis, Copper compounds, Iodine compounds, Catalysis -- Analysis, Aromatic compounds, Cyclic compounds -- Composition, Amines, Chemical tests and reagents -- Composition, Biological sciences, Chemistry
Abstract

Research has been conducted on martinellic acid. Results demonstrate that this compound can be synthesized via guanylation reaction of guanylation reagent with tricyclic triamine.

Published
2003

2. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Author

Joseph Kelleher, Yan Wang, AnneMarie Culazzo Pferdekamper, Jun Liu, Fangxian Sun, Stephanie Kay Dodd, Melissa Matsumoto, Nathan P. Englund, Xu Wu, Jeffrey Tsao, Juliet Williams, Jing Yuan, Dai Cheng, Yun Jiang, Jiqing Jiang, Anthony Vattay, Wenqi Gao, Tove Tuntland, Markus Warmuth, Yung-mae Yao, Stefan Peukert, Ribo Guo, Yongqin Wan, Wieslawa Maniara, Karen Miller-Moslin, Dong Han, Shifeng Pan, and Marion Dorsch

Subjects
Organic Chemistry, Antagonist, Pharmacology, Biochemistry, Sonidegib, Hedgehog signaling pathway, Blockade, chemistry.chemical_compound, Smoothened Receptor, chemistry, Drug Discovery, Smoothened, Antagonism, Hedgehog
Abstract

The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism of the Smoothened receptor (Smo). Structure−activity relationship studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)biphenyl-3-carboxamide (5m, NVP-LDE225), which is currently in clinical development.

Published
2010

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