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With the miniaturization and integration of electronic components in wireless communication and wearable devices, the demand for low-cost flexible composites with temperature-stable high dielectric constant and low loss has substantially increased. However, such comprehensive properties are fundamentally difficult to combine for conventional conductive and ceramic composites. Here, we develop silicone elastomer (SE) composites based on hydrothermally grown MoS 2 on tissue paper-derived cellulose carbon (CC). Such design promoted the formation of microcapacitors, multiple interfaces, and defects reinforcing interfacial and defect polarizations and resulting in a high dielectric constant of 9.83 at 10 GHz with low filler loading of 15 wt %. Unlike highly conductive fillers, MoS 2 @CC with low conductivity ensured a very low loss tangent of 7.6 × 10 -3 , which was also influenced by the filler dispersion and adhesion to the matrix. Apart from breaking the typical conflict between high dielectric constant and low losses of traditional conductive composites, MoS 2 @CC SE composites were highly flexible with temperature-stable dielectric properties making them attractive as flexible substrates in microstrip antenna applications and extreme environment electronics. Moreover, recycling from waste tissue paper makes them potential candidates as low-cost and sustainable dielectric composites.

Parkinson's disease (PD) is the second most common neurodegenerative disorder; however, its etiology remains elusive. Antioxidants are considered to be a promising approach for decelerating neurodegenerative disease progression owing to extensive examination of the relationship between oxidative stress and neurodegenerative diseases. In this study, we investigated the therapeutic effect of melatonin against rotenone-induced toxicity in the Drosophila model of PD. The 3-5 day old flies were divided into four groups: control, melatonin alone, melatonin and rotenone, and rotenone alone groups. According to their respective groups, flies were exposed to a diet containing rotenone and melatonin for 7 days. We found that melatonin significantly reduced the mortality and climbing ability of Drosophila because of its antioxidative potency. It alleviated the expression of Bcl 2, tyrosine hydroxylase (TH), NADH dehydrogenase, mitochondrial membrane potential, and mitochondrial bioenergetics and decreased caspase 3 expression in the Drosophila model of rotenone-induced PD-like symptoms. These results indicate the neuromodulatory effect of melatonin, and that it is likely modulated against rotenone-induced neurotoxicity by suppressing oxidative stress and mitochondrial dysfunctions., Competing Interests: The authors declare no competing financial interest., (© 2023 The Authors. Published by American Chemical Society.)

Alzheimer's disease (AD) is a very complicated and multifactorial neurological disorder having limited therapeutic interventions illustrated by the impairment in memory and cognitive function. Several lines of confirmation are stoutly connected with mitochondrial function perturbation as a significant causative factor in AD, while the molecular mechanisms involved in AD pathogenesis are still poorly understood. Minocycline, a well-known antibiotic, has confirmed efficacy against mitochondrial defects and oxidative stress as a neuroprotective effect. In view of this property, we examined the remedial effect of minocycline on AD. To attain insight into the molecular machinery responsible for AD pathogenesis, we preferred the UAS/GAL4 scheme for the development of AD in flies that overexpress the Aβ42 protein in the brain of Drosophila . The warning signs like the declined lifespan, locomotion deficit and memory loss, impaired mitochondrial membrane potential, and increased caspase 3 expression with mitogen-associated protein kinases linked with AD pathogenesis were examined in the existence of minocycline. Minocycline halted the Aβ42-induced symptoms including behavioral changes and altered the mitochondrial membrane potential along with apoptotic factors' protein expression (JNK/p-JNK and caspase 3). Thus, the current study could be functional to find out the role of minocycline in human Aβ42-overexpressed transgenic AD flies., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)