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Aiming at the problem of gas emissions caused by the high-pressure operation of a large industrial gas (O 2 , N 2 , and Ar) pipeline network, this study establishes a mathematical model of the oxygen transmission and distribution system (OTDS) based on TGNET software. In addition, the study conducts transient simulation, comprehensively considering theoretical constraints and actual operation requirements, and adopts a large air separation company for the OTDS as a case study. After comparing two traditional adjustment methods, a compressor short stop adjustment strategy is proposed to reduce the peak pressure of the pipe network system. This study determines the energy-saving benefits and the difference in the scope of application of compressor short-stop adjustment. Compared with the medium-pressure release and inlet guide vane opening adjustment (IGVOA) strategies, the compressor short-stop adjustment strategy reduced oxygen emission by 3850.9 Nm 3 and increased by 927.1 Nm 3 . Furthermore, the compressor operating energy consumption was reduced by 3349 and 2919 kW h. Compared with the IGVOA strategy, the compressor short-stop adjustment strategy has increased the application range of compressor inlet pressure and medium-pressure pipeline pressure by more than 70%. This strategy is effective for reducing the emission of pipeline gases caused by fluctuations in user demand., Competing Interests: The authors declare no competing financial interest., (© 2021 The Authors. Published by American Chemical Society.)