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Start Over Author "Ling You" Publisher american chemical society
5 results on '"Ling You"'

3. Semen Phthalate Metabolites, Spermatozoa Apoptosis, and DNA Damage: A Cross-Sectional Study in China.

Author

Ling You, Yi-Xin Wang, Qiang Zeng, Min Li, Yue-Hui Huang, Yu Hu, Wen-Cheng Cao, Ai-Lin Liu, and Wen-Qing Lu

Subjects
*PHTHALATE esters, *MALE reproductive organs, *DNA damage, *APOPTOSIS, *SPERMATOZOA physiology
Abstract

Toxicological studies have shown that phthalates, a class of widely used chemicals, can impair male reproductive function, but epidemiological evidence is in consistent This study aimed to investigate the associations of semen phthalate metabolites with sperm apoptosis and DNA damage in a Chinese population. We assessed sperm apoptosis markers with Annexin V/PI analysis and sperm DNA integrity with comet assay before measuring eight phthalate metabolites in semen by high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS ) among 463 men from Wuhan, China. We found a suggestive do se-response relationship between semen mono-(2-ethylhexyl) phthalate (MEHP) and an increased percentage of Annexin V7PF sperm (p for trend of <0.10). We also observed that semen monomethyl phthalate (MMP) and monoethyl phthalate (MEP) were associated with significant dose-related increases in tail length of the comet (both p for trend of < 0.01). In conclusion, our data indicate that semen MEHP is associated with increased sperm apoptosis and that semen MMP and MEP are associated with increased sperm DNA damage in a Chinese population. [ABSTRACT FROM AUTHOR]

Published
2015
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5. Natural and Engineered Pest Management Agents

Author

PAUL A. HEDIN, JULIUS J. MENN, ROBERT M. HOLLINGWORTH, BRUCE D. HAMMOCK, Koji Nakanishi, Richard J. Stonard, Stephen W. Ayer, John J. Kotyk, Leo J. Letendre, Carolyn I. McGary, Thomas E. Nickson, Ngo LeVan, Paul B. Lavrik, John M. Clough, David A. Evans, Paul J. de Fraine, Torquil E. M. Fraser, Christopher R. A. Godfrey, David Youle, H. Mrozik, Shuji Takahashi, Mutsuo Nakajima, Takeshi Kinoshita, Hideyuki Haruyama, Soji Sugai, Toyokuni Honma, Sadao Sato, Tatsuo Haneishi, Horace G. Cutler, Dale J. Hansen, John Cuomo, Mamunur Khan, Rex T. Gallagher, William P. Ellenberger, Phillip R. Jefferies, John E. Casida, Muraleedharan G. Nair, Pierre Escoubas, Labunmi Lajide, Junya Mizutani, R. F. Severson, R. V. W. Eckel, D. M. Jackson, V. A. Sisson, M. G. Stephenson, Edward P. Masler, J. R. Miller, J. L. Spencer, A. J. Lentz, J. E. Keller, E. D. Walker, J. F. Leykam, Ronald J. Nachman, Jefferson W. Tilley, Timothy K. Hayes, G. Mark Holman, Ross C. Beier, Robert B. Harris, Jun ling You, Saskia C. F. Milton, Raymond C.DeLisle Milton, N. S. Rangaraju, Christop, PAUL A. HEDIN, JULIUS J. MENN, ROBERT M. HOLLINGWORTH, BRUCE D. HAMMOCK, Koji Nakanishi, Richard J. Stonard, Stephen W. Ayer, John J. Kotyk, Leo J. Letendre, Carolyn I. McGary, Thomas E. Nickson, Ngo LeVan, Paul B. Lavrik, John M. Clough, David A. Evans, Paul J. de Fraine, Torquil E. M. Fraser, Christopher R. A. Godfrey, David Youle, H. Mrozik, Shuji Takahashi, Mutsuo Nakajima, Takeshi Kinoshita, Hideyuki Haruyama, Soji Sugai, Toyokuni Honma, Sadao Sato, Tatsuo Haneishi, Horace G. Cutler, Dale J. Hansen, John Cuomo, Mamunur Khan, Rex T. Gallagher, William P. Ellenberger, Phillip R. Jefferies, John E. Casida, Muraleedharan G. Nair, Pierre Escoubas, Labunmi Lajide, Junya Mizutani, R. F. Severson, R. V. W. Eckel, D. M. Jackson, V. A. Sisson, M. G. Stephenson, Edward P. Masler, J. R. Miller, J. L. Spencer, A. J. Lentz, J. E. Keller, E. D. Walker, J. F. Leykam, Ronald J. Nachman, Jefferson W. Tilley, Timothy K. Hayes, G. Mark Holman, Ross C. Beier, Robert B. Harris, Jun ling You, Saskia C. F. Milton, Raymond C.DeLisle Milton, N. S. Rangaraju, and Christop

Published
1993

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