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Your search keyword '"Llop S"' showing total 5 results
Start Over Author "Llop S" Publisher american chemical society
5 results on '"Llop S"'

2. Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study

Author

Sarzo B, Ballesteros V, Iñiguez C, Manzano-Salgado CB, Casas M, Llop S, Murcia M, Guxens M, Vrijheid M, Marina LS, Schettgen T, Espada M, Irizar A, Fernandez-Jimenez N, Ballester F, and Lopez-Espinosa MJ

Subjects
Perfluoroalkyl substances, TSH, Deiodinase genes, FT4, TT3
Abstract

Results of studies on perfluoroalkyl substances (PFASs) and thyroid hormones (THs) are heterogeneous, and the mechanisms underlying the action of PFASs to target THs have not been fully characterized. We examined the relation between first-trimester maternal PFAS and TH levels and the role played by polymorphisms in the iodothyronine deiodinase 1 (DIO1) and 2 (DIO2) genes in this association. Our sample comprised 919 pregnant Spanish women (recruitment = 2003-2008) with measurements of perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), and free thyroxine (FT4), and we genotyped for single-nucleotide polymorphisms in the DIO1 (rs2235544) and DIO2 (rs12885300) genes. We performed multivariate regression analyses between PFASs and THs and included the interaction term PFAS-genotypes in the models. PFHxS was associated with an increase in TSH (% change in outcome [95% CI] per 2-fold PFAS increase = 6.09 [-0.71, 13.4]), and PFOA and PFNA were associated with a decrease in TT3 (-7.17 [-13.5, -0.39] and -6.28 [-12.3, 0.12], respectively). We found stronger associations between PFOA, PFNA, and TT3 for DIO1-CC and DIO2-CT genotypes, although interaction p-values were not significant. In conclusion, this study found evidence of an inverse association between PFOA and TT3 levels. No clear effect modification by DIO enzyme genes was observed.

Published
2021

3. Prenatal Exposure to Polybrominated Flame Retardants and Fetal Growth in the INMA Cohort (Spain)

Author

Lopez-Espinosa MJ, Costa O, Vizcaino E, Murcia M, Fernandez-Somoano A, Iñiguez C, Llop S, Grimalt JO, Ballester F, and Tardon A

Subjects
endocrine system
Abstract

Our aim was to investigate the relation between PBDEs and fetal growth or newborn anthropometry in a Spanish cohort (2003-2008). PBDE congeners (BDE-47, -99, -153, -154, and -209) were determined in serum of 670 mothers at gestational week 12 and in 534 umbilical cord samples. Abdominal circumference (AC), estimated fetal weight (EFW), femur length (FL), and biparietal diameter (BPD) during gestation were measured by ultrasounds. At birth, weight (BW), head circumference (HC), and length (BL) were also measured. We assessed growth in the intervals between 12-20 and 20-34 weeks of gestation and size at birth by standard deviation (SD)-scores adjusted for constitutional characteristics. We conducted multivariate linear regression analyses between PBDE congeners and their sum (Sigma PBDEs) and outcomes. We found statistically significant inverse associations between Sigma PBDEs and AC, EFW, and BPD at weeks 20-34 and HC at birth. Regarding congeners, the association was clearer with BDE-99, with inverse associations being found with AC, EFW, and BPD at weeks 20-34, and with BW and HC at delivery. These outcomes decreased between 1.3% and 3.5% for each 2-fold PBDE increase. Concerning matrices, we found statistically significant inverse associations with BPD, HC, and BW when using maternal serum, and for AC and EFW with cord serum. In conclusion, PBDEs may impair fetal growth in late pregnancy and reduce birth size.

Published
2015

4. Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children.

Author

Soler-Blasco R, Llop S, Riutort-Mayol G, Lozano M, Vallejo-Ortega J, Murcia M, Ballester F, Irizar A, Andiarena A, Fernandez-Jimenez N, Braeuer S, and Harari F

Subjects
Pregnancy, Female, Humans, Child, Preschool, Child, Genetic Predisposition to Disease, Methyltransferases genetics, Methyltransferases metabolism, Cacodylic Acid urine, Apolipoproteins E genetics, Aryldialkylphosphatase genetics, Arsenic toxicity, Arsenicals urine
Abstract

We explored the influence of child and maternal single nucleotide polymorphisms (SNPs) in genes related to neurological function and arsenic metabolism (i.e., ABCA1 , ABCB1 , PON1 , CYP3A , BDNF , GSTP1 , MT2A , and APOE as well as AS3MT ) on the association between prenatal arsenic (As) exposure and methylation efficiency and neuropsychological development in 4-5-year-old children. Participants were 549 mother-child pairs from the INMA (Environment and Childhood) Spanish Project. We measured inorganic arsenic (iAs) and the metabolites monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in urine samples collected during pregnancy. Neuropsychological development was assessed at the age of 4-5 years using the McCarthy Scales of Children's Abilities (MSCA). Several SNPs were determined in maternal and child DNA; AS3MT and APOE haplotypes were inferred. The median ∑As (sum of iAs, DMA, and MMA) was 7.08 μg/g creatinine. Statistically significant interactions for children's APOE haplotype were observed. Specifically, ε4-carrier children had consistently lower MSCA scores in several scales with increasing ∑As and MMA concentrations. These results provide evidence regarding the neurotoxic effects of early life exposure to As, observing that the APOE ε4 allele could make children more vulnerable to this exposure.

Published
2023
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5. Maternal origin and other determinants of cord serum organochlorine compound concentrations in infants from the general population.

Author

Vizcaino E, Grimalt JO, Lopez-Espinosa MJ, Llop S, Rebagliato M, and Ballester F

Subjects
Adult, Cohort Studies, Female, Humans, Infant, Newborn, Pregnancy, Young Adult, Fetal Blood chemistry, Hydrocarbons, Chlorinated blood, Maternal Exposure, Prenatal Exposure Delayed Effects blood
Abstract

Organochlorine compounds (OCs), including pesticides and polychlorobiphenyls (PCBs), were determined in the serum of 499 cord blood samples from infants born during 2004-2006 in Valencia (Spain). The concentrations were found to be correlated with the region of origin of the mothers. Those from Latin-America gave birth to infants with higher 4,4'-DDE and 4,4'-DDT concentrations than those from Europe. On the contrary, European mothers had children with higher concentrations of hexachlorobenzene and PCBs than Latin-American mothers. These associations were independent of maternal period of stage in Valencia. Data examination with a multivariate model including maternal region of origin described 39-44% of the concentration variability of 4,4'-DDE and total PCBs with statistic significance. Other maternal variables found to significantly influence OC burden in newborns were age, education level, and body mass index (BMI). In general, older women, with higher education standards and higher BMI had infants with higher OC serum concentrations than younger women, with lower education scores and low BMI. The increase of 4,4'-DDT in newborns from mothers with high education levels and high BMI suggest that dissimilar maternal diets may be at the origin of some of these OC body burden differences.

Published
2010
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