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The multifunctional rigid-rod Beta-barrel pores offers a good platform to study chemical processes that take place within their confined, oriented, inert and functionalized internal nanospace. The first molecular mechanics modeling (MacroModel, MMFF94) of multifunctional rigid-rod Beta-barrel pore hosts 1 with internal 1,3,6-pyrenetrisulfonate guests is reported.

Supra-molecular architectures containing lanthanide ions because of their intrinsic magnetic, spectroscopic, and optical properties are focused. It is shown that absorption spectra, combined with electrochemical data, demonstrate the dual effect associated with attachment of the sulfonamide group.

The first oriented multicolored antiparallel redox gradients (OMARG-SHJs) with two-component redox gradients are described in both the electron- and hole-transporting pathways. The presence of both gradients is essential for achieving photoinduced charge separation over very long distances.

The synthesis, characterization, and zipper assembly of yellow p-oligophenyl naphthalenediimide (POP-NDI) donor-acceptor hybrids are described. The results suggested that characteristics such as significant critical thickness, strong photocurrents, large fill factors, and smooth surfaces are important for optoelectronic performance and support of the existence of highly ordered architectures.

The studies related to design, synthesis, oxidation potentials and quadrupole moments of a complete collection of dialkoxynaphthalenes (DAN) and DAN amplifiers is reported. The results demonstrate that synthetic pores that operate by ion-pair-assisted [pi]-clamping are capable of regioisomer recognition responding to structural differences as subtle as the one between 2,6- and 2,7-DAN isomers.

A report on the design, synthesis, and evaluation of multifunctional pores with electron-deficient naphthalenediimide (NDI) [pi]-clamps at their inner surface for molecular recognition by aromatic electron donor-acceptor interactions is presented. The [pi]-clamping by aromatic electron donor-acceptor interactions is introduced as an attractive concept to complement molecular recognition within synthetic multifunctional pores with interactions.

The plum-colored charge-transfer complexes formed by dialkoxynaphthalene (DAN) donors and naphthalenediimide (NDI) acceptors are introduced to create synthetic ion channels with a novel rigid-rod pi-stack architecture that open in response to guest binding. The results obtained confirmed the potential of the new rigid-rod pi-stack architecture to expand the practical usefulness of synthetic multifunctional ion channels and pores toward electron-transfer processes.

The synthetic multifunctional pore that opens rather than close in response to chemical stimulation is reported. The rational design of synthetic multifunctional pores can be of practical use for the continuous fluorometric detection of chemical processes.

The design, synthesis and evaluation of [pi]-acidic, shape-persistent oligo-(p-phenylene)-N,N-naphthalenediimide (O-NDI) rods are reported that can transport anions across lipid bilayer membranes with rare halide VI selectivity and a substantial anomalous mole fraction effect (AMFE). The rare halide VI sequence of neutral O-NDI rods, together with reduced selectivity and halide sequence but increased activity with one cationic rod terminus, are in agreement with operational dynamic anion-[pi] interactions.

A Fourier transform ion cyclotron resonance spectroscopic study based on dissociative proton attachment of bridgehead bromides, chlorides and alcohols was conducted to determine the gas-phase stability of bridgehead carbocations. Results confirm the original hypothesis that bridgehead derivatives solvolyse by a common mechanism and that the stability of the intermediate carbenium ions is reflected in the transition state of the reaction.

Different nanotubes were prepared from two triblock copolymers. Chemistry was performed on the nanotubes so that one type contained amino terminal groups and the other bore carboxyl terminal groups. The amino and carboxyl groups were reacted by amidization to join the nanotubes head to tail to yield nanotube multiblocks. The block copolymer nanotube multiblocks (CONATUBLOCs) may be viewed as a macroscopic counterpart of block copolymers. Like block copolymers, the different blocks of the CONATUBLOCs segregated from one another not only in a block-selective solvent mixture but also in the solid state. [ABSTRACT FROM AUTHOR]

The article focuses on the study conducted in Geneva, Switzerland regarding the development of rigid oligonaphthalenediimide rods as transmembrane anion. The authors discuss the design, synthesis and evaluation of oligonaphthalenediimide rods that can transport anions across lipid bilayer membranes. Moreover, they talk about the strategies to design synthetic anion channels beyond ion pairing and hydrogen bonding.

The article presents information on aromatic electron donor-acceptor interactions used for constructing synthetic ion channels that open in response to chemical stimulation. Synthetic multifunctional pores were introduced to combine molecular translocation with molecular recognition and transformation for practical applications, such as the detection of chemical reactions. The plum-colored charge-transfer complexes formed by dialkoxynaphthalene donors and naphthalenediimide acceptors, a classical motif in supramolecular chemistry, are introduced to create synthetic ion channels with a novel rigid-rod &pie;-stack architecture that open rather than close in response to guest binding.

Synthetic ion channels and pores attract current attention as multicomponent sensors in complex matrixes. This application requires the availability of reactive signal amplifiers that covalently capture analytes and drag them into the pore. π-Basic 1,5-dialkoxynaphthalenes (1,5-DAN) are attractive amplifiers because aromatic electron donor-acceptor (AEDA) interactions account for their recognition within π-acidic naphthalenediimide (NDI) rich synthetic pores. Focusing on amplifier design, we report here the synthesis of a complete collection of DAN and dialkoxyanthracene amplifiers, determine their oxidation potentials by cyclic voltammetry, and calculate their quadrupole moments. Blockage experiments reveal that subtle structural changes in regioisomeric DAN amplifiers can be registered within NDI pores. Frontier orbital overlap in AEDA complexes, oxidation potentials, and, to a lesser extent, quadrupole moments are shown to contribute to isomer recognition by synthetic pores. Particularly important with regard to practical applications of synthetic pores as multianalyte sensors, we further demonstrate that application of the lessons learned with DAN regioisomers to the expansion to dialkoxyanthracenes provides access to privileged amplifiers with submicromolar activity. [ABSTRACT FROM AUTHOR]

The article presents a molecular analysis of multifunctional pores with electron-deficient naphthalenediimide clamps by aromatic electron donor-acceptor interactions. The authors compared that clamp free pore 2 to determine the specific contributions from clamping to molecular recognition within pore 1. The results confirm that the availability of synthetic pores that respond to chemical stimulation other than ion pairing will greatly expand their practical usefulness as sensors and beyond.

Synthetic ion channels and pores formed by rigid-rod molecules are summarized. This includes work on hydrogen-bonded chains installed along membrane-spanning rigid-rod scaffolds to transport protons. As a second topic, programmed assembly of p-septiphenyls with terminal iminodiacetate-copper complexes for potassium transport by cation-pi interactions is described. The third topic concerns rigid push-pull rods as fluorescent alpha-helix mimics to probe the importance of dipole-potential interactions for voltage gating, both on the functional and the structural level. Topic number four deals with p-octiphenyl staves as key scaffolds for the synthesis of rigid-rod beta-barrel pores. The description of internal and external design strategies for these rigid-rod beta-barrels covers a rich collection of pH-, pM-, voltage-, ligand-, and enzyme-gated synthetic multifunctional pores that can act as hosts, sensors, and catalysts. As far as practical applications are concerned, the possibility to detect chemical reactions with synthetic multifunctional pores appears most attractive. Recent molecular mechanics simulations are presented as a valuable approach to insights on the elusive suprastructures of multifunctional pores made from rigid rods.