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1. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension

Author

Wienk, Hans, Lammers, Ivonne, Hotze, Anna, Jin Wu, Wechselberger, Rainer W., Owens, Ray, Stammers, David K., Stuart, David, Kaptein, Robert, and Folkers, Gert E.

Subjects
Cysteine -- Chemical properties, Histidine -- Chemical properties, Protein folding -- Analysis, Zinc finger proteins -- Chemical properties, Zinc finger proteins -- Structure, Biological sciences, Chemistry
Abstract

The structure of the tandem zinc-finger region of human ZHX1 protein related to the occurrence of certain cancers was determined to understand the function and structure of the individual ZHX domains. The results showed that both zinc-fingers (ZNF1 and ZNF2) adopted canonical [beta][beta][alpha]-folds in which a zinc ion is coordinated by two cysteine and two histidine residues while the C-terminal extension to ZNF2 forms two [beta]-strands to form a [beta]-sheet with the [beta]-strands of this zinc-finger.

Published
2009

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