1. Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface.
- Author
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Piccoli J, Hein R, El-Sagheer AH, Brown T, Cilli EM, Bueno PR, and Davis JJ
- Subjects
- Base Sequence, C-Reactive Protein chemistry, Electric Capacitance, Humans, Oligopeptides chemistry, Aptamers, Nucleotide chemistry, Biosensing Techniques methods, C-Reactive Protein analysis, DNA chemistry, Electrochemical Techniques methods
- Abstract
Electrochemical immunosensors offer much in the potential translation of a lab based sensing capability to a useful "real world" platform. In previous work we have introduced an impedance-derived electrochemical capacitance spectroscopic analysis as supportive of a reagentless means of reporting on analyte target capture at suitably prepared mixed-component redox-active, antibody-modified interfaces. Herein we directly integrate receptive aptamers into a redox charging peptide support in enabling a label-free low picomolar analytical assay for C-reactive protein with a sensitivity that significantly exceeds that attainable with an analogous antibody interface.
- Published
- 2018
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