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Your search keyword '"Ranjala Ratnayake"' showing total 1 results
Start Over Author "Ranjala Ratnayake" Publisher american chemical society
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1. Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, from Phyllanthus engleri.

Author

Ranjala Ratnayake, David Covell, Tanya T. Ransom, Kirk R. Gustafson, and John A. Beutler

Subjects
*PLANT extracts, *CANCER cell growth regulation, *RENAL cell carcinoma, *PHYLLANTHUS, *CELL lines, *BIOINFORMATICS, *SESQUITERPENES
Abstract

An extract from Phyllanthus engleriwas identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively inhibited the growth of renal cancer cell lines. Bioassay-guided fractionation yielded two new guaiane sesquiterpenes, englerins A (1) and B (2). Englerin A showed 1000-fold selectivity against six of eight renal cancer cell lines with GI50values ranging from 1−87 nM. The structures of 1and 2and their relative stereochemistry were established by spectroscopic methods. [ABSTRACT FROM AUTHOR]

Published
2009
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