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Research has been conducted on the (+)-8-deoxyvernolepin and its 11,13-dihydroderivative. The enantioselective synthesis of these compounds has been carried out and the results indicate that the employed synthetic strategy is useful for the enantioselective preparation of (+)-vernolepin-related compounds from germacrolides.

Research has been conducted on eudesmanolides which are the sequiterpene lactones' main skeletal types. The results of the straightforward synthesis of such eudesmanolides as (+)-3alpha-hydroxyreynosin and (+)-8beta-hydroxyasterolide carried out via different solvents and additives and containing exocyclic double bond are reported.

A bioinspired and sustainable procedure for the straightforward synthesis of (±)-aureol has been achieved in eight steps (14% overall yield) from epoxyfarnesol. The key steps are the titanocene(III)-catalyzed radical cascade cyclization of an epoxyfarnesol derivative and a biosynthetically inspired sequence of 1,2-hydride and methyl shifts. [ABSTRACT FROM AUTHOR]

An experimental study on the role played by each of the reagents involved in the selective reduction of aromatic ketones in aqueous medium is reported. In this reaction, the reduction of aromatic ketones is mediated by Cp2TiCl. Moreover, the presence of Mn in the reaction medium is mandatory. To account for these findings, a substantially revised mechanism is proposed. [ABSTRACT FROM AUTHOR]

The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C-C bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A. [ABSTRACT FROM AUTHOR]

[reaction: see text] A general procedure for the synthesis of both 12,6- and 12,8-eudesmanolides has been developed. The key step is the titanocene-catalyzed radical cyclization of accessible epoxygermacrolides. The novel reagent 2,4,6-trimethyl-1-trimethylsilylpyridinium chloride, both compatible with oxiranes and capable of regenerating Cp(2)TiCl(2) from Cp(2)Ti(Cl)H and Cp(2)Ti(Cl)OAc, played an important role in the catalytic cycle leading to exocyclic alkenes.