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The origin of the charge density wave (CDW) is a long-term open issue. Furthermore, the evolution of phonon-phonon interactions (PPIs) across CDW transitions has rarely been investigated. Whether electron-phonon coupling (EPC) would be weakened or enhanced after CDW transitions is still under debate. Additionally, CDW provides fertile ground for uncovering intriguing intermediate electronic states. Here, we report a Raman spectroscopy study of the PPI and EPC in topological semimetal EuAl 4 exhibiting a CDW phase below temperature T c ≈ 145 K. The free-charge-carrier-density ( n c ) and temperature dependences of the Fano asymmetric factors (1/ |q| ) of the two phonon modes A 1g and B 1g indicate that below T c , the EPC becomes weakened probably due to the reduction of the n c . Interestingly, in the temperature range of 50-145 K, the steep growth of the 1/| q | leading to the significant deviation from the linear dependence on the n c , together with the shoulder-like features in the temperature evolutions of the 1/| q | and the n c around 50 K, implies the possible existence of an intermediate electronic state with the EPC distinctly larger than the CDW ground state in EuAl 4 . Furthermore, below T c , the faster decrease in the full width at half maximum of the B 1g phonon mode representing the collective vibrations of the CDW-modulated Al 1 atoms suggests remarkable growth of the PPI for the B 1g phonon mode after the CDW phase transition, which is in contrast to the weakening of the EPC and thus may mainly arise from the strengthening of lattice anharmonicity in EuAl 4 . Our results not only highlight the significance of the enhanced PPI and the weakened EPC in completely understanding the formation of the CDW phase but also initiate the exploration of novel intermediate electronic states in EuAl 4 .

MXenes are emerging materials renowned for their exceptional conductivity, abundant functional groups, and excellent solution processability, making them highly promising as conductive-additive-free inks for flexible electronic devices. However, current preparation methods are hampered by low yields of MXene flakes so that substantial waste MXene sediments (MS) are generated. Here, we demonstrate a type of conductive ink with appropriate rheological properties, namely MG inks formulated using MS and graphene oxide (GO), for screen-printing frequency selective surface (FSS). GO facilitates interlayer interactions by covalently cross-linking with MXene flakes, resulting in a denser structure and significantly enhancing the conductivity of the best-performing MG-based ink to 849 S cm -1 . Additionally, GO serves as a binder to considerably improve the rheological properties of MS, thus enabling high-quality printing on various substrates. The close stacking of MS and GO not only improves the oxidation resistance but also maintains conductivity above 97% even after 60 days. Furthermore, the MG-based FSS produced via straightforward screen printing demonstrates excellent performance and retains its functionality after 90 days of operation. This MS-based ink formulation represents a strategy of "turning trash into treasure" and highlights the potential of MS for the next generation of electronic devices.

Small-cell lung cancer (SCLC) represents a significant public health challenge due to its increasing incidence and high mortality. Most SCLC patients are diagnosed at advanced stages, and there are limited effective targeted therapies available. In this study, a potent and selective CDK9 degrader, C3 , was developed through PROTAC modification of the CDK9 inhibitor, AT-7519. C3 effectively induced apoptosis in various SCLC cell lines at low nanomolar concentrations and demonstrated favorable in vivo tolerance and adequate oral bioavailability. Notably, PROTAC C3 significantly reduced the proliferation of primary tumor samples from patients in mini-PDX models. Our findings indicate that the targeted degradation of CDK9 could become a viable strategy for treating SCLC, highlighting its potential therapeutic value. Additionally, this research offers a general structural optimization and evaluation strategy to improve the degradative selectivity, metabolic stability, and oral availability of PROTAC molecules.

Viscoelasticity is the mechanical feature of living tissues and the cellular extracellular matrix (ECM) and has been recognized as an essential biophysical cue in cell function and fate regulation, tissue development and homeostasis maintenance, and disease progression. These findings provide new insights for the development of biomaterials with comparable viscoelastic properties as native ECMs and the tissue matrix, displaying promising applications in regeneration medicine. In this review, the relationship between matrix viscoelasticity and tissue functions (e.g., development and regeneration) in physiological conditions and disease progression (e.g., aging, degenerative, fibrosis, and tumor) in pathological conditions will be especially highlighted to figure out the potential therapeutic target for disease treatment and inspiration for tissue regeneration related biomaterial development. Furthermore, findings and an understanding of the cell response to ECM viscoelasticity and the mechanism behind it are comprehensively summarized to provide a pathophysiological basis for viscoelastic biomaterials design. The advances of viscoelastic biomaterials on defect tissue repair are also reviewed, suggesting the significance of the native matrix matchable microenvironment on tissue regeneration. Although challenging, tunable viscoelastic biomaterials that match the mechanical properties of native tissues and ECMs show great promise. They could promote tissue regeneration, treat degenerative diseases, and support the development of organoids and artificial organs.

Imine-containing azaarene-based triarylmethanes are vital molecular motifs that are prevalent in a wide array of bioactive compounds. Recognizing the limitations of current synthetic methodologies─marked by a scarcity of examples and difficulties in flexible functional group modulation─we have developed an efficient and modular asymmetric photochemical strategy employing pyridotriazoles and boronic acids as substrates. Utilizing novel chiral diamine-derived pyrroles and primary amines as catalysts, we successfully synthesized a diverse range of triarylmethanes with high yields and excellent enantioselectivities. This method not only exhibits a broad substrate scope and outstanding functional group tolerance but also enables the precise synthesis of deuterated derivatives using inexpensive D 2 O as the deuterium source. Mechanistic studies reveal that an unusual 1,4-boron shift is a critical step in generating the boronated enamine intermediate, while also shedding light on the potential enantiocontrol mechanisms facilitated by the chiral catalyst.

Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the T cell receptor signaling pathway and is therefore a target of interest for immunooncology. Nonselective HPK1 inhibitors may affect other kinase components of T cell activation, blunting the beneficial impact of enhanced T cell activity that results from HPK1 inhibition itself. Here, we report the discovery of pyrazine carboxamide HPK1 inhibitors and their optimization through structure-based drug design to afford a highly selective HPK1 inhibitor, compound 24 (AZ3246). This compound induces IL-2 secretion in T cells with an EC 50 of 90 nM without inhibiting antagonistic kinases, exhibits pharmacokinetic properties consistent with oral dosing, and demonstrates antitumor activity in the EMT6 syngeneic mouse model.

Antimicrobial peptides are a promising strategy to combat antimicrobial resistance. However, the experimental discovery of antimicrobial peptides is both time-consuming and laborious. In recent years, the development of computational technologies (especially deep learning) has provided new opportunities for antimicrobial peptide prediction. Various computational models have been proposed to predict antimicrobial peptide. In this review, we focus on deep learning models for antimicrobial peptide prediction. We first collected and summarized available data resources for antimicrobial peptides. Subsequently, we summarized existing deep learning models for antimicrobial peptides and discussed their limitations and challenges. This study aims to help computational biologists design better deep learning models for antimicrobial peptide prediction.

Constructing a hollow porous ZnO-ZnS sphere is still a big challenge due to the difficulty in controlling the morphology and distribution of ZnO shell originating from the fact that ZnO prefers to grow along particular crystal planes. Here, we demonstrate a novel synthetic strategy for the preparation of oxygen-vacancy-enriched ZnO-ZnS hollow porous (Ov-ZOS (HP)) spheres by combining the concepts of adopting a template-directed method, selecting the sulfidation precursor, and tuning the calcination process of the template. Structural characterization and density functional theory (DFT) calculations reveal that hollow porous nanostructures and oxygen vacancies in the ZnO-ZnS heterojunction are beneficial in promoting efficient charge transfer and separation. The optimized Ov-ZOS (HP) exhibits enhanced rates of hydrogen evolution reaction (71.86 mmol h -1 g -1 ), which is 1.48, 2.08, and 3.0 times higher than those of ZnO-ZnS hollow porous spheres, oxygen vacancy-enriched ZnO-ZnS nanosheets, ZnO-ZnS nanosheets, respectively. Moreover, the Ov-ZOS (HP) presents excellent cyclability for photocatalytic hydrogen evolution. Therefore, this study provides physical insights into controlling the hollow porous nanostructures of various semiconductor heterojunctions that are hard to form through other existing strategies for solar energy utilization.

Current lithium batteries experience significant performance degradation under extreme temperature conditions, both high and low. Traditional wide-temperature electrolyte designs typically addressed these challenges by manipulating the solvation sheath and selecting solvents with extreme melting/boiling points. However, these solvent-mediated solutions, while effective at one temperature extreme, invariably fail at the opposite end due to the inherent difficulties in maintaining solvent stability across wide temperatures. Herein, we report the use of the main lithium salt to simultaneously address interfacial challenges at both extremely high and low temperatures. This approach is different from the conventional solvent-mediated strategies. As a proof of concept, we utilized lithium nitrate (LiNO 3 ) to establish an anion-controlled solvation structure and electric double layer. The formulated electrolytes exhibited remarkable performance across temperature extremes, retaining 56.1% capacity at -60 °C and sustaining 400 stable cycles at 80 °C. In contrast, electrolytes based on current solvent-mediated strategies failed to operate at -60 °C and could not exceed 50 cycles at 80 °C. By shifting the focus to the main salt rather than the solvent, our work offers the possibility of addressing the enduring challenges of electrolyte stability across a broad temperature range.

Hepatocellular carcinoma (HCC) is a common malignancy and generally develops from liver cirrhosis (LC), which is primarily caused by the chronic hepatitis B (CHB) virus. Reliable liquid biopsy methods for HCC screening in high-risk populations are urgently needed. Here, we establish a porous silicon-assisted laser desorption ionization mass spectrometry (PSALDI-MS) technology to profile metabolite information hidden in human serum in a high throughput manner. Serum metabolites can be captured in the pore channel of APTES-modified porous silicon (pSi) particles and well-preserved during storage or transportation. Furthermore, serum metabolites captured in the APTES-pSi particles can be directly detected on the LDI-MS without the addition of an organic matrix, thus greatly accelerating the acquisition of metabolic fingerprints of serum samples. The PSALDI-MS displays the capability of high throughput (5 min per 96 samples), high reproducibility (coefficient of variation <15%), high sensitivity (LOD ∼ 1 pmol), and high tolerance to background salt and proteins. In a multicenter cohort study, 1433 subjects including healthy controls (HC), CHB, LC, and HCC volunteers were enrolled and nontargeted serum metabolomic analysis was performed on the PSALDI-MS platform. After the selection of feature metabolites, a stepwise diagnostic model for the classification of different liver disease stages was constructed by the machine learning algorithm. In external testing, the accuracy of 91.2% for HC, 71.4% for CHB, 70.0% for LC, and 95.3% for HCC was achieved by chemometrics. Preliminary studies indicated that the diagnostic model constructed from serum metabolic fingerprint also displays good predictive performance in a prospective observation. We believe that the combination of PSALDI-MS technology and machine learning may serve as an efficient tool in clinical practice.

The high responsivity and broad spectral sensitivity of organic photodetectors (OPDs) present a bright future of commercialization. However, the relatively high dark current density still limits its development. Herein, two novel nonpolar p-type conjugated small molecules, NSN and NSSN, are synthesized as interface layers to enhance the performance of the OPDs, which not only can tune energy alignments and increase the reverse charge injection barrier but also can reduce the interfacial trap density. Moreover, benefiting from the smoother surface morphology and enhanced conductivity, the NSN exhibited superior charge transport and collection properties. Consequently, the OPD with NSN achieved a dark current density of 0.37 nA cm -2 and a high specific detectivity of 2.77 × 10 13 Jones at -2 V. More importantly, the optimized OPDs can be successfully integrated into optical communication systems, demonstrating precise digital signal communication without obvious distortion, showing promising application potential in the wireless transmission system.

Proton ( 1 H) NMR spectroscopy presents a powerful tool for biomass mixture studies by revealing the involved chemical compounds with identified ingredients and molecular structures. However, conventional 1 H NMR generally suffers from spectral congestion when measuring biomass mixtures, particularly biomass carbohydrate samples, that contain various physically and chemically similar compounds. In this study, a targeted detection NMR approach, DREAMTIME, is exploited for studying biomass carbohydrate mixtures by spectroscopically targeting the desired compounds in separate 1D NMR spectra. From three model mixtures, namely, the C 6 sugar isomerization mixture, C 5 sugar catalytic hydrogenation mixture, and d-glucose and d-xylose fermentation mixture, to a real reaction mixture of sucrose hydrolysis, DREAMTIME achieves satisfactory performance in compound identification and mixture analysis even when mixture signals are crowded and overlapped in conventional 1 H NMR. Additionally, DREAMTIME is performed in a rapid 1D acquisition manner, making it available for highly efficient analysis on various biomass reactions. Our results suggest that DREAMTIME provides an effective method for wide applications to complex biomass mixture analysis with explicit compound identification, targeted component monitoring, and conversion reaction detection.

A novel sesquiterpene lactone derivative, vernonolide A ( 1 ), featuring an unprecedented carbon skeleton, along with its plausible biosynthetic precursor, vercinolide I ( 2 ), and eight known sesquiterpene lactones ( 3 - 10 ) were isolated and characterized from the whole plants of Vernonia cinerea (L.). The structures of 1 and 2 were elucidated using nuclear magnetic resonance spectroscopic analysis and calculated and experimental electronic circular dichroism spectra. A plausible biosynthetic pathway for 1 was proposed. Notably, compounds 8 and 10 exhibited significant inhibitory effects on tumor necrosis factor-α-induced nuclear factor-κB activity, with IC 50 values of 0.95 and 5.57 μM, respectively.

Transketolase (TKL; EC 2.2.1.1) has been identified as a potential new herbicide target. In order to discover highly herbicidal active compounds targeting TKL and improve their structural diversity for lead compounds, a series of pyrazole-carboxamides 7a - 7v were designed and synthesized through structural optimization for pyrazole-containing phenoxy amide compound 4u . Among the synthesized compounds, compound 7r possessed excellent herbicidal efficacy against Digitaria sanguinalis ( Ds ) and Amaranthus retroflexus ( Ar ) by the small cup method (the inhibition about 95%, 100 mg/L) and the foliar spray method (the inhibition over 90%, 150 g ai/ha) in a greenhouse, which were superior to that of the positive control nicosulfuron. More significantly, compound 7r displayed good crop selectivity toward both maize and wheat even at 375 g of ai/ha. The studies on mode of action (MOA) of high herbicidal active compounds, including the enzyme inhibition activity, fluorescent quenching experiments, and molecular docking analysis between Setaria viridis ( Sv )TKL and ligand, suggested that compound 7r acts as a typical TKL inhibitor, and the benzothiazole ring is an important motif for Sv TKL inhibition activity. Above all, compound 7r could be a potential candidate for the development of herbicides with new MOA for weed control in maize and wheat field.

Indium phosphide (InP)-based quantum dot light-emitting diodes (QLEDs) are promising for future lighting and display applications due to their high color purity and brightness. However, their efficiency and stability are often limited by the disordered structure of the widely used poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS), which impairs charge transport. Herein, we present a strategy to enhance the performance of InP-based QLEDs by modifying PEDOT:PSS through interfacial dipole modulation using molybdenum oxide (MoO x ) nanoparticles. The strong hydrogen bonding between MoO x and PSS creates strong dipole-dipole interactions, reducing the separation of PEDOT-rich regions, enhancing π-π stacking and conductivity. This optimization facilitates balanced electron and hole injection, increasing external quantum efficiency (EQE) from 12.2% in control devices to 17.8% in the treated devices, along with a brightness enhancement from 32,998 to 43,567 cd m -2 . Notably, our treated devices exhibit a reduction in efficiency attenuation compared to other reported InP-based QLEDs, particularly at high brightness levels of 5000 and 10,000 cd m -2 , with EQE attenuation of only 4 and 9%, respectively, compared to 16 and 30% for controls. This work highlights the potential of dipole engineering in advancing InP-based QLED technology, providing a pathway for developing high-performance, stable, and eco-friendly lighting and displays.

Resistive random access memory (RRAM) has emerged as a promising candidate for next-generation storage technologies due to its simple structure, high running speed, excellent durability, high integration density, and low power consumption. This paper focuses on the application of organic-inorganic hybrid perovskite (OIHP) materials in RRAM by introducing an innovative three-dimensional POPA modification strategy, which is realized by binding octa-amine-polyhedral oligomeric silsesquioxanes (8NH 2 -POSS) onto the side chains of poly(acrylic acid) (PAA), thereby enhancing the material's resilience under elevated temperatures and humidity conditions. POPA cross-links with perovskite grains at crystalline boundaries through multiple -NH 3 + and -C═O chemical anchoring sites on its branch chain, enhancing the grain adhesion, optimizing the film quality, and improving the cage structure distribution at the perovskite grain boundaries. The experimental results demonstrate that the POPA-modified OIHP RRAM exhibits an excellent resistance switching performance, with an optimal ON/OFF ratio of 5.0 × 10 5 s. After 150 days of environmental exposure, the ON/OFF ratio remains at 1.0 × 10 4 s. After 150 days of environmental exposure, the ON/OFF ratio remains at 1.0 × 10 5 , indicating good stability. Furthermore, the POPA modification endows the perovskite film with considerable flexibility, maintaining stable resistance switching performance under various bending radii. This study provides a vital reference for flexible, high-performance, and long-lifespan perovskite memory devices.

A molecular dynamics model for picosecond laser ablation of nanoscale silicon carbide crystals was established by linearly scaling the laser focal diameter, and the correlation between the molecular dynamic simulation of the nanoscale and the experimental reproduction of the microscale was achieved. The calculation accuracy of the molecular dynamic model was verified by ablating the surface of silicon carbide wafers with a laser pulse width of 37 ps. On this basis, this paper further investigated the influence of the laser pulse width and fluence on the surface ablation damage and modification width, threshold, and lattice temperature. The results showed that, when the laser pulse width is higher than 10 ps, the silicon carbide damage threshold increases with increasing the pulse width, while the modification threshold is almost unaffected by the pulse width. In addition, the influence of crystal orientation has been studied, and laser irradiation along the [1-100] crystal orientation induces a higher peak temperature, larger damage, and modification width and threshold, followed by irradiation along the [0001] crystal orientation and lowest along the [11-20] crystal orientation. Finally, with the linear scaling value increasing, the spatial distribution of the laser energy field deviates more from the actual situation, resulting in the calculated results being more consistent with the experimental results. Through this paper, it is demonstrated that this linearly scaled molecular dynamics model can be used to study laser ablation results over tens of micrometers.

Naringenin (4,5,7-trihydroxyflavone, NAR) is an effective active ingredient in Rhizoma Drynariae , which has many biological functions, encompassing anti-inflammatory and -oxidant functions. Prior research has shown that NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes possessed a significant contribution to osteoporosis. However, the NAR impact on bone loss caused by microgravity remains unclear. Classical microgravity simulation methods were used to induce simulated microgravity (SMG) in mice and cells. Microcomputed tomography, immunohistochemical examination, and hematoxylin and eosin staining were implemented to ascertain alterations in bone microstructure and morphology in mice subsequent to NAR gavage. Cellular investigations were implemented encompassing quantitative real-time polymerase chain reaction, Western blotting, and immunofluorescence labeling to investigate the molecular mechanism behind NAR resistance to microgravity-induced bone loss. Our research has shown that NAR can significantly enhance the SMG-stimulated alterations in bone microstructure and morphology in mice, mainly by increasing the trabecular thickness, bone volume fraction, and trabecular number while increasing the bone trabecula number. Cell experiments also showed that SMG caused the activation of inflammatory corpuscles of NLRP3 and induced pyroptosis simultaneously, which can be confirmed by the upregulation of protein and mRNA expression levels such as those of NLRP3, cleaved caspase-1, gasdermin D, and apoptosis-associated speck-like protein. The occurrence of pyroptosis further led to the disorder of osteogenic differentiation, which showed that the osteopontin, Runt-related transcription factor 2, bone morphogenetic protein 2, and alkaline phosphatase expression levels were decreased. The intervention of NAR can activate the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway, reverse this phenomenon via controlling the reactive oxygen species generation in cells and correcting mitochondrial malfunction, weaken the pyroptosis of osteoblasts (OBs), and promote osteogenic differentiation. In summary, NAR could hinder the pyroptosis of OBs caused by SMG and promote osteogenic differentiation via activating the Nrf2/HO-1 pathway. This provides a unique view for inhibiting bone loss under weightlessness and confirms the NAR capacity in treating microgravity-stimulated bone loss, giving new ideas and methods for future space medicine development.

In response to the growing demand for global health monitoring, we report a nonintrusive health detection method using a compact, conformal wearable ultraviolet (UV)-assisted gas-sensing system based on an intrinsically flexible porous polydimethylsiloxane (PDMS)-zinc oxide (ZnO) composite layer (PPZL) for the breath acetone (BrAce) detection and breath event analysis. The enhanced acetone response is attributed to the synergistic effect of UV irradiation and the high surface area of the porous structure, which also improves the mechanical robustness. The UV-assisted wearable sensor reliably detects acetone concentrations ranging from 1 to 100 ppm at room temperature under 4.05 mW/cm 2 UV intensity, even under mechanical strains such as a bending radius of 5 mm and 60% tensile strain. It accurately analyzes different breathing patterns (12-20 breaths per minute) and BrAce concentrations, maintaining a stable performance over 20 days with less than 5% signal degradation. The sensor exhibits response and recovery times of average 110-150 and 130-180 s, respectively, and maintains a consistent 3 ppm BrAce response under varying humidity levels up to 70% relative humidity, ensuring accurate detection of BrAce concentrations during real-world breath tests. Additionally, the sensor targets only specific gases, and the sensor's selectivity is not a key concern. This flexible acetone gas sensor offers a portable solution for health management and a fabrication method for designing flexible metal oxide materials.

The accurate understanding of mass transfer in molten salt contributes to revealing the reaction mechanism and advancing the technologies. The existence of notable natural convection effects has been demonstrated in our previous studies, even though the driving forces for such a high natural convection are still not clear. Herein, we showed that the intense natural convection in molten salts resulted from severe heat dissipation through the electrodes (or the system). With an adiabatic design, natural convection effects were significantly suppressed in molten LiCl-KCl. The derived value of the natural convection layer (δ conv ) ranged from 190 to 250 μm in molten LiCl-KCl containing a redox couple (e.g., SmCl 3 , EuCl 3 , and CrCl 3 ), comparable to those in aqueous solutions. The values of δ conv in LiCl-KCl-173 mM CrCl 3 increased to ∼360 μm due to the change in salt viscosity. The density-driven convection became dominant under a high redox concentration, and the increasing working temperature had no apparent effect on the natural convection effects because of the adiabatic design.

Plants perceive and orchestrate defense responses when herbivorous insects are ovipositing. Fruits, as a crucial reproductive organ in plants, have rarely been researched on the responses to insect eggs. Here, we found that oviposition by the specialist insect Bactrocera minax in navel oranges activated the lignin synthesis pathway and cell division, causing mechanical pressure that crushed the eggs. Transcriptome and metabolome analyses revealed an enrichment of oviposition-induced genes and metabolites within the lignin synthesis pathway, which was confirmed by histochemical staining. Furthermore, hydrogen peroxide (H 2 O 2 ) accumulation was observed at the oviposition sites. Plant defense-related hormones jasmonic acid (JA) and salicylic acid (SA) exhibited rapid induction after oviposition, while indole-3-acetic acid (IAA) activation occurred in the later stages of oviposition. Additionally, secondary metabolites induced by prior egg deposition were found to influence larval performance. Our studies provide molecular evidence that host fruits have evolved defense mechanisms against insect eggs and pave the way for future development of insect-resistant citrus varieties.

Domino cyclization of oxime esters and NH 4 SCN facilitated by photoredox and copper cocatalysis has been established. Various structurally diverse fully substituted 2-aminothiazoles have been obtained in good yields at room temperature. It is featured by mild conditions, favorable functional group tolerance, and wide substrate scope. The present reaction is amenable to gram-scale synthesis, which is expected to find potential applications in organic synthesis and drug discovery. A plausible reaction mechanism is proposed.

The direct carboxylation of aldehydes with CO 2 is rare due to the polarity mismatch between these two electrophilic substrates. To address this challenge, we propose a sequential approach for synthesizing α-ketoacids from commercially available aldehydes by integrating umpolung and CO 2 shuttling strategies. This transition metal-free shuttle carboxylation method enables the transfer of CO 2 from triphenylacetic acid potassium salt to thioacetal, eliminating the need for handling pressurized CO 2 gas or using specialized equipment, while also enhancing the reaction's functional group tolerance. Furthermore, the use of stoichiometric or slightly excess amounts of triphenylacetic acid potassium salt as a formal CO 2 donor makes it suitable for complete 1 3 C labeling of α-ketoacids.

Biocatalytic processes using microorganisms are considered efficient and economically and environmentally friendly reactions. However, the viability and function of these microorganisms are prone to being hindered by various practical environments. Here, we reported a bacteria-induced nanochannel structure that endowed the microorganism with biocatalytic ability in harsh conditions. We revealed that the bacteria could trigger the fusion of silica nanoparticles on their surface by the secreted alkaline metabolite, resulting in silica shells with nanochannels on bacteria (bacteria@nSiO 2 ). The nanochannel structure in silica shells endowed bacteria with biocatalytic ability in multiple harsh conditions. We revealed that these nanochannels could influence the mass transfer from the extracellular to the intracellular environment, which protected the bacteria from excessive toxic substance while preserving the mass exchange during biocatalysis. This feature ensured bacteria@nSiO 2 with efficient bioactivity under harsh conditions for industrial catalysis and degradation of pollution, which cannot be achieved by corresponding native bacteria. Using the crude oil spill as a practical example, we presented that bacteria@nSiO 2 could degrade highly concentrated crude oil, which any reported bacteria cannot achieve. This work emphasized the role of nanochannels in the regulation of cellular functions for enhanced biocatalysis. It also demonstrated a bacteria-triggered nanostructure formation, which is a promising methodology for nanotechnology and provides a strategy for more advanced organism-material hybrids.

Diabetic foot ulcers (DFUs) are a significant challenge in the clinical care of diabetic patients, often necessitating limb amputation and compromising the quality of life and life expectancy of this cohort. Minimally invasive therapies, such as modular scaffolds, are at the forefront of current DFU treatment, offering an efficient approach for administering therapeutics that accelerate tissue repair and regeneration. In this study, we report a facile method for fabricating granular nanofibrous microspheres (NMs) with predesigned structures and porosities. The proposed technology combines electrospinning and electrospraying to develop a therapeutic option for DFUs. Specifically, porous NMs were constructed using electrospun poly(lactic- co -glycolic acid) (PLGA):gelatin short nanofibers, followed by gelatin cross-linking. These NMs demonstrated enhanced cell adhesion to human dermal fibroblasts (HDF) during an in vitro cytocompatibility assessment. Notably, porous NMs displayed superior performance owing to their interconnected pores compared to nonporous NMs. Cell-laden NMs demonstrated higher Young's modulus values than NMs without loaded cells, suggesting improved material resiliency attributed to the reinforcement of cells and their secreted extracellular matrix. Dynamic injection studies on cell-laden NMs further elucidated their capacity to safeguard loaded cells under pressure. In addition, porous NMs promoted host cell infiltration, neovascularization, and re-epithelialization in a diabetic mouse wound model, signifying their effectiveness in healing diabetic wounds. Taken together, porous NMs hold significant potential as minimally invasive, injectable treatments that effectively promote tissue integration and regeneration.

Achieving structural and stereogenic diversity from the same starting materials remains a fundamental challenge in organic synthesis, requiring precise control over the selectivity. Here, we report divergent catalytic methods that selectively yield either cycloaddition or addition/elimination products from bicyclo[1.1.0]butanes and α,β-unsaturated ketones. By employing chiral Lewis acid or Brønsted acid catalysts, we achieved excellent regio-, diastereo-, and enantioselectivity across all three distinct transformations, affording a diverse array of synthetically valuable chiral bicyclo[2.1.1]hexanes and cyclobutenes. The divergent outcomes are controlled by the differential activation of the substrates by the specific chiral catalyst with the reaction conditions dictating the pathway selectivity. This strategy demonstrates the power of divergent catalysis in creating molecular complexity and diversity, offering a valuable tool for the synthesis of enantioenriched chiral building blocks.

Active antibiotic-resistant bacteria (ARB) play a major role in spreading antimicrobial resistance (AMR) in the environment; however, they have remained largely unexplored. Herein, we coupled bio-orthogonal noncanonical amino acid tagging with high-throughput fluorescence-activated single-cell sorting (FACS) and sequencing to characterize the phenome and genome of active ARB in complex environmental matrices. Active ARB, conferring resistance to six antibiotics throughout wastewater treatment, were distinguished and quantified. The percentage and concentration of active ARB ranged from 0.28% to 45.3% and from 1.1 × 10 4 to 2.09 × 10 7 cells/mL, respectively. Notably, the final effluents retained up to 4.79 × 10 4 cells/mL of active ARB. Targeted FACS and genomic sequencing revealed a distinct taxonomic composition of active ARB compared with that of the overall population. The coexistence of antibiotic resistome and mobilome in active ARB was also identified, including three high-quality metagenomic assembly genomes assigned to pathogenic bacteria, highlighting the substantial health risks due to their activity, phenotypic resistance, mobility, and pathogenicity. This study advances our understanding of previously overlooked active ARB in the environment by linking their resistance phenotype to their genotype. This high-throughput method will enable efficient quantitative surveillance of active AMR, providing valuable insights into risk control and management.

Photoferroelectrics that involve strong light-matter coupling are regarded as promising candidates for realizing bulk photovoltaic and photoelectric effects via light absorption. Nonetheless, understanding the photoresponse mechanism or modulation of performance from a microscopic point of view is scarcely explored through quantification of macroscopic properties. Herein, we design a model material, Gd 3+ -doped (K 0.5 Na 0.5 )NbO 3 ferroelectric-transparent ceramics, and present an advantageous strategy to enhance the optoelectronic coupling through joint modulations of lattice distortion and oxygen vacancies, along with inner defects and ferroelectric domains. Significantly, their microcosmic manipulation can be intuitively and facilely evaluated by the optical transparency of each ceramic. An approximately 10 4 fold increase in conductivity under ultraviolet irradiation was produced. Under the cocoupling between external physical fields, the synergy of photoelectric stimulation increased the photoconductivity of the ceramics by 13.89 times. Additionally, a significant increase (4.5-fold) in the current output from the photovoltaic effect was achieved via ferroelectric domains of moderate size, whose size could be easily assessed by optical transmittance. In situ microscopic observations confirmed that the configuration of oxygen vacancy-dependent ferroelectric domains contributes to the enhanced optoelectronic response. This research provides a distinct way to develop inexpensive optocoupler devices and meet the requirements for multifunctional integration in single photoferroelectrics.

Owing to its multiple fascinating properties of renewability, biodegradability, biocompatibility, and antibacterial activity, chitin is expected to become a green cornerstone of next-generation functional materials. Chitin nanofibers, as building blocks, form multiscale hierarchical structures spanning nano- and macrolevels in living organisms, which pave the way for sophisticated functions. Therefore, from a biomimetic perspective, exploiting chitin nanofibers for use in multifunctional, high-performance materials is a promising approach. Here, we first summarize the latest advances in the multiscale hierarchical structure assembly mode of chitin and its derivative nanofibers, including top-down exfoliation and bottom-up synthesis. Subsequently, we emphasize the environmental impacts of these methods, which are crucial for whether chitin nanofibers can truly contribute to a more eco-friendly era. Furthermore, the latest progress of chitin nanofibers in environmental and medical applications is also discussed. Finally, the potential challenges and tailored solutions of chitin nanofibers are further proposed, covering raw material, structure, function, manufacturing, policies, etc.

Parthenolide is a germacrane sesquiterpene lactone separated from the traditional medicinal plant feverfew. Previous studies have shown that parthenolide possesses many pharmacological activities, involving anti-inflammatory and anticancer activities. However, the antitumor mechanism of parthenolide has not been fully elucidated. Thus, we investigate the potential antitumor mechanisms of parthenolactone. We predicted through network pharmacology that parthenolide may target HIF-1α to interfere with the occurrence and development of cancer. We found that parthenolide inhibited PD-L1 protein synthesis through mTOR/p70S6 K /4EBP1/eIF4E and RAS/RAF/MEK/MAPK signaling pathways and promoted PD-L1 protein degradation through the lysosomal pathway, thereby inhibiting PD-L1 expression. Immunoprecipitation and Western blotting results demonstrated that parthenolide inhibited PD-L1 expression by suppressing HIF-1α and RAS cooperatively. We further proved that parthenolide inhibited cell proliferation, migration, invasion, and tube formation via down-regulating PD-L1. Moreover, parthenolide increased the effect of T cells to kill tumor cells. In vivo xenograft assays further demonstrated that parthenolide suppressed the growth of tumor xenografts. Collectively, we report for the first time that parthenolide enhanced T cell tumor-killing activity and suppressed cell proliferation, migration, invasion, and tube formation by PD-L1. The current study provides new insight for the development of parthenolide as a novel anticancer drug targeting PD-L1.

Current development of inverted p-i-n perovskite solar cells (PSCs), with nickel oxide as the hole transport layer, is progressing toward lower net costs, higher efficiencies, and superior stabilities. Unfortunately, the high density of defect-based traps on the surface of perovskite films significantly limits the photoelectric conversion efficiency and operational stability of perovskite solar cells. Finding cost-effective interface modifiers is crucial for the further commercial development of p-i-n PSCs. In the present work, we report a passivation strategy using a multifunctional molecule, benzocaine hydrochloride (BHC), which is shown to reduce defect density and enhance the photovoltaic performance and stability of the resultant p-i-n PSCs. It has been revealed that BHC strongly interacts with perovskite precursor components and triggers the evolution of the perovskite absorber film morphology and enables improved surface energy level alignment, thus promoting charge carrier transport and extraction. These properties are beneficial for improving open-circuit voltage ( V OC ) and fill factor (FF). Our results show that the photoelectric conversion efficiency (PCE) of p-i-n PSCs with nickel oxide as the hole transport layer increased from an initial 20.0% to 22.1% after being passivated with BHC, and these passivated devices also exhibited improved stability. DFT calculations reveal the unusual ability of the BHC passivant to improve band alignment while also preventing the accumulation of holes at the interface. In this work, the advantages of BHC passivation are demonstrated by linking theoretical calculations with optical and electrical characterizations.

Nanoparticle (NP) delivery systems have been actively exploited for cancer therapy and vaccine development. Nevertheless, the major obstacle to targeted delivery lies in the substantial liver sequestration of NPs. Here we report a DNA-engineered approach to circumvent liver phagocytosis for enhanced tumor-targeted delivery of nanoagents in vivo. We find that a monolayer of DNA molecules on the NP can preferentially adsorb a dysopsonin protein in the serum to induce functionally invisibility to livers; whereas the tumor-specific uptake is triggered by the subsequent degradation of the DNA shell in vivo. The degradation rate of DNA shells is readily tunable by the length of coated DNA molecules. This DNA-engineered invisibility cloaking (DEIC) is potentially generic as manifested in both Ag 2 S quantum dot- and nanoliposome-based tumor-targeted delivery in mice. Near-infrared-II imaging reveals a high tumor-to-liver ratio of up to ∼5.1, approximately 18-fold higher than those with conventional nanomaterials. This approach may provide a universal strategy for high-efficiency targeted delivery of theranostic agents in vivo.

19 F magnetic resonance imaging ( 19 F MRI) is gaining attention as an emerging diagnostic technology. Effective 19 F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time ( T 2 ), short longitudinal (or spin-lattice) relaxation time ( T 1 ), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric 19 F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on T 2 was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a T 2 of 612 ms. This hyperbranched polymeric 19 F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for 19 F MRI CAs.

Biomolecular condensates are dynamic liquid droplets through intracellular liquid-liquid phase separation that function as membraneless organelles, which are highly involved in various complex cellular processes and functions. Artificial analogs formed via similar pathways that can be integrated with biological complexity and advanced functions have received tremendous research interest in the field of synthetic biology. The coacervate droplet-based compartments can partition and concentrate a wide range of solutes, which are regarded as attractive candidates for mimicking phase-separation behaviors and biophysical features of biomolecular condensates. The use of peptide-based materials as phase-separating components has advantages such as the diversity of amino acid residues and customized sequence design, which allows for programming their phase-separation behaviors and the physicochemical properties of the resulting compartments. In this Perspective, we highlight the recent advancements in the design and construction of biomimicry condensates from synthetic peptides relevant to intracellular phase-separating protein, with specific reference to their molecular design, self-assembly via phase separation, and biorelated applications, to envisage the use of peptide-based droplets as emerging biomedical delivery vehicles.

In this work, a long-wave infrared (LWIR) quantum dot (QD) spectrometer was constructed for the first time by integrating a 255-element HgSe QD filter array with an LWIR array detector. The filter array was fabricated using a combination inkjet printing strategy with eight types of T-dodecyl mercaptan-terminated HgSe QD inks. The stability and morphology of the QDs were improved by optimizing the purification methodology and ligand modification. Combined with the compressive-sensing-based least-squares linear regression (CS-LS) algorithm, the LWIR QD spectrometer achieved a spectral resolution of 5.4 cm -1 over a wide spectral range of 8 to 14 μm, enabling the detection of the chemical warfare agent simulant dimethyl methylphosphonate. This technology is expected to facilitate the development of smaller volumes and more accurate identification of various targets in the future. This paper offers an approach to fabricating low-cost LWIR spectrometers and promoting the scale-up applications of QD devices.

Photothermal responsive hydrogels are widely used in bionic soft actuators due to their remote-controlled capabilities and flexibility. However, their weak mechanical properties and limited responsiveness hinder their potential applications. To overcome this, we developed an innovative laponite/MXene/PNIPAm (L x M y PN) nanocomposite hydrogel that is mechanically robust and exhibits excellent photothermally responsive properties based on abundant hydrogen bonds. Notably, laponite clay is used as a co-cross-linking agent to improve the mechanical properties of L x M y PN hydrogel, while MXene nanosheets are added to promote the photothermal responsiveness. The resulting L 3 M 0.4 PN nanocomposite hydrogel exhibits enhanced mechanical properties, with a compressive strength of 0.201 MPa, a tensile strength of 90 kPa, and a fracture toughness of 27.25 kJ m -2 . In addition, the L 3 M 0.4 PN hydrogel displays a deswelling ratio of 73.6% within 60 s and experiences an excellent volume shrinkage of 82.4% under light irradiation. Furthermore, hydrogel actuators with fast response behaviors are constructed and employed as grippers capable of grasping and releasing target objects. Overall, this high-strength and fast-responsive hydrogel actuator is beneficial to paving the way for remote controlled soft robots.

The repair of large bone defects poses a significant challenge in orthopedics. Polyetheretherketone (PEEK) is a promising bone substitute, while it suffers a lack of bioactivity. Although several studies have been performed to further improve the bioactivities of PEEK by various surface modifications, PEEK offering long-term, multifaceted biofunctionalities remains still desired. In this study, we introduced metal-organic frameworks (MOFs), specifically ZIF-8 loaded with celecoxib (ZIF-8(CEL)), onto the PEEK surface through dopamine adhesion. The resulting PEEK@ZIF-8(CEL) aims to achieve long-term stable release of Zn ions and CEL for enhanced bone integration. Material characterization and biological experiments confirmed the successful integration of ZIF-8(CEL) onto PEEK and its positive biomedical effects, including creating a positive bone immunological environment and promoting bone growth. This study demonstrates the potential of PEEK@ZIF-8(CEL) as a novel repair material for large bone defects, offering a promising alternative in orthopedic applications.

Mitochondrial DNA (mtDNA) is pivotal for mitochondrial morphology and function. Upon mtDNA damage, mitochondria undergo quality control mechanisms, including fusion, fission, and mitophagy. Real-time monitoring of mtDNA enables a deeper understanding of its effect on mitochondrial function and morphology. Controllable induction and real-time tracking of mtDNA dynamics and behavior are of paramount significance for studying mitochondrial function and morphology, facilitating a deeper understanding of mitochondria-related diseases. In this work, a fluorescent platinum complex was designed and developed that not only induces mitochondrial DNA (mtDNA) aggregation but also triggers mitochondrial autophagy (mitophagy) through the MDV pathway for damaged mtDNA clearance in living cells. Additionally, this complex allows for the real-time monitoring of these processes. This complex may serve as a valuable tool for studying mitochondrial microautophagy and holds promise for broader applications in cellular imaging and disease research.

While photochemical deracemization significantly enhances atom economy by eliminating the necessity for additional oxidants or reductants, the laborious presynthesis of substrates from feedstock chemicals is often required, thereby compromising the practicality of this method. In this study, we propose a novel approach known as de novo deracemization synthesis, which involves direct utilization of simple substrates undergoing both photochemical transformation and reversible photochemical transformation. The efficient enantiocontrol of chiral catalysts in the latter process establishes an effective platform for deracemization. This alternative and practical approach to address the challenges of asymmetric photocatalysis has been successfully demonstrated in the photosensitized de novo deracemization synthesis of azaarene-functionalized cyclobutanes featuring three stereocenters, including an all-carbon quaternary center. By exclusively employing a suitable chiral catalyst to enable kinetically controlled [2 + 2] photocycloreversion, we pave a creative path toward achieving more cost-effective photochemical deracemization.

Solar energy is an ideal clean and inexhaustible energy source. Solar-driven formic acid (FA) dehydrogenation is one of the promising strategies to address safety and cost issues related to the storage, transport, and distribution of hydrogen energy. For FA dehydrogenation, the O-H and C-H cleavages are the key steps, and developing a photocatalyst with the ability to break these two bonds is critical. In this work, both density functional theory (DFT) calculation and experimental results confirmed the positive synergistic effect between brookite and rutile TiO 2 for O-H and C-H cleavage in HCOOH. Further, brookite TiO 2 is beneficial to the generation of the • OH radical and significantly promotes C-H cleavage in formate. Under optimized conditions, the H 2 production efficiency of FA dehydrogenation can reach up to 30.4 μmol·mg -1 ·h -1 , which is the highest value compared with similar reported TiO 2 -based systems and over 1.7 times the reported highest value of Au 0.75 Pd 0.25 /TiO 2 photocatalysts. More importantly, after more than 42 days (>500 h) of irradiation, the system still demonstrated high H 2 production activity, indicating the potential for practical application. This work provides a valuable strategy to improve both the efficiency and stability of photocatalytic FA dehydrogenation under mild conditions.

Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, the aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited the research on their targeting and anticancer mechanism. Then, a series of aggregation-induced emission (AIE)-activated butyltin(IV)-iridium(III) imidazole-phenanthroline complexes were prepared in this study. Complexes exhibited significant fluorescence improvement in the aggregated state because of the restricted intramolecular rotation (RIR), accompanied by an absolute fluorescence quantum yield of up to 29.2% (IrSn9). Complexes demonstrated potential in vitro antiproliferative and antimigration activity against A549 cells, following a lysosomal-mitochondrial apoptotic pathway. Nude mouse models further confirmed that complexes had favorable in vivo antitumor and antimigration activity in comparison to cisplatin. Therefore, butyltin(IV)-iridium(III) imidazole-phenanthroline complexes possess the potential as potential substitutes for platinum-based drugs.

This study evaluated alkylresorcinol concentration (ARC) in recombinant inbred lines (RILs) from the cross of Zhongmai 578 and Jimai 22 in three environments. ARC exhibited a continuous distribution ranging from 337.4 to 758.0, 495.4-768.0, and 456.3-764.7 μg/g, respectively, in three environments. Analysis of variance (ANOVA) indicated significant ( P < 0.001) impacts of genotypes, environments, and their interactions. The broad-sense heritability of ARC was 0.76. Genome-wide linkage mapping analysis identified four stable quantitative trait loci (QTL) for ARC on chromosomes 2A, 3A, 4D, and 7A. Kompetitive allele-specific PCR (KASP) marker of each QTL was developed and validated in 206 representative wheat varieties. Wheat varieties harboring 0, 1, 2, 3, and 4 favorable alleles had ARC of 499.1, 587.8, 644.7, 668.5, and 711.1 μg/g, respectively. This study suggests that combining multiple minor-effect QTL through KASP markers can serve as an effective strategy for breeding high-ARC wheat, thereby enhancing innovations in functional food production.

The integration of umpolung and carbon isotope exchange for accessing isotopically labeled α-keto acids through photoredox catalysis is elucidated. This process involves the carbonyl umpolung of C(sp 2 )-α-keto acids to yield C(sp 3 )-α-thioketal acids, followed by the carbon isotope exchange of C(sp 3 )-α-thioketal acids, and ultimately, deprotection to generate carbon-labeled α-keto acids.

Effective synthesis and application of single-atom catalysts on supports lacking enough defects remain a significant challenge in environmental catalysis. Herein, we present a universal defect-enrichment strategy to increase the surface defects of CeO 2 -based supports through H 2 reduction pretreatment. The Pt catalysts supported by defective CeO 2 -based supports, including CeO 2 , CeZrO x , and CeO 2 /Al 2 O 3 (CA), exhibit much higher Pt dispersion and CO oxidation activity upon reduction activation compared to their counterpart catalysts without defect enrichment. Specifically, Pt is present as embedded single atoms on the CA support with enriched surface defects (CA-HD) based on which the highly active catalyst showing embedded Pt clusters (Pt C ) with the bottom layer of Pt atoms substituting the Ce cations in the CeO 2 surface lattice can be obtained through reduction activation. Embedded Pt C can better facilitate CO adsorption and promote O 2 activation at Pt C -CeO 2 interfaces, thereby contributing to the superior low-temperature CO oxidation activity of the Pt/CA-HD catalyst after activation.

Reported herein is a practical, economical, and efficient construction of 3-alkylated quinoxalin-2(1 H )-ones with alkyl carboxylic acids and alkyl iodides by quinoxalin-2(1 H )-one excitation and cobaloxime catalysis. Primary, secondary, and tertiary alkyl iodides and carboxylic acids all could be efficiently transferred into target products with excellent functional group tolerance. Mechanism studies reveal that the quinoxalin-2(1 H )-one derivatives could be directly excited and yield alkyl carbon radicals from alkyl carboxylic acids and alkyl iodides with the aid of the cobaloxime complex.

Lithium-rich manganese-based layered oxides (LRMOs) have recently attracted enormous attention on account of their remarkably big capacity and high working voltage. However, some inevitable inherent drawbacks impede their wide-scale commercial application. Herein, a kind of Cr-containing Co-free LRMO with a topical spinel phase (Li 1.2 Mn 0.54 Ni 0.13 Cr 0.13 O 2 ) has been put forward. It has been found that the high valence of Cr 6+ can reduce the Li + ion content and induce the formation of a local spinel phase by combining more Li + ions, which is beneficial to eliminate the phase boundary between the spinel phase and the bulk phase of the LRMO material, thus dramatically avoiding phase separation during the cycling process. In addition, the introduction of Cr can also expand the layer spacing and construct a stronger Cr-O bond compared with Mn-O, which enables to combine the transition metal (TM) slab to prevent the migration of TM ions and the transformation of the bulk phase to the spinel phase. Simultaneously, the synergistic effect of the successfully constructed spinel-layered biphase interface and the strong Cr-O bond can effectively impede the escape of lattice oxygen during the initial activation process of Li 2 MnO 3 and provide the fast diffusion path for Li + ion transmission, thus further reinforcing the configurable stability. Besides, Cr-LRMO presents an ultrahigh first discharge specific capacity of 310 mAh g -1 , an initial Coulombic efficiency of as high as 92.09%, a good cycling stability (a capacity retention of 94.70% after 100 cycles at 1C), and a small voltage decay (3.655 mV per cycle), as well as a good rate capacity (up to 165.88 mAh g -1 at 5C).

Elastic electromagnetic fibers are promising building blocks for next-generation flexible electronics. However, fabrication of elastic fibers is still difficult and usually requires organic solvents or high temperatures, restricting their widespread applications. Furthermore, the continuous production of electromagnetic fibers has not been realized previously. In this study, we propose an ionic chelation strategy to continuously produce electromagnetic fibers with a magnetic liquid metal (MLM) as the core and elastic polyurethane as the sheath in water at room temperature. Sodium alginate (SA) has been introduced to rapidly chelate with calcium ions (Ca 2+ ) in a coagulation bath to support the continuous spinning of waterborne polyurethane (WPU) as a sheath. Meanwhile, WPU-encapsulated MLM microparticles efficiently suppress the fluid instability of MLM for continuous extrusion as the core. The resultant fiber exhibits excellent mechanical performances (tensile strength and toughness up to 32 MPa and 124 MJ/m 3 , respectively), high conductive stability in large deformations (high conductivity of 7.6 × 10 4 S/m at 580% strain), and magnetoactive properties. The applications of this electromagnetic fiber have been demonstrated by conductance-stable wires, sensors, actuation, and electromagnetic interference shielding. This work offers a water-based molecular principle for efficient and green fabrication of multifunctional fibers and will inspire a series of applications.