Author: "Sabrina Castellano" / Publisher: american chemical society - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Sabrina Castellano" Publisher american chemical society

Author: Gianluca Sbardella, Antonello Mai, Sara Bartolini, Sabrina Castellano, Roberto Cirilli, Dante Rotili, Ciro Milite, Marisabella Santoriello, Serena Orlando, Ilaria Sciamanna, Annalucia Serafino, Patrizia Lavia, and Corrado Spadafora
Published: 2011
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Author: Sabrina Castellano, Dirk Kuck, Marina Sala, Ettore Novellino, Frank Lyko, and Gianluca Sbardella
Subjects: *LEUKEMIA, *ANEMIA, *LEAD compounds, *LOCAL anesthetics
Abstract: Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most potent compound, derivative 3b, was also able to induce a recognizable demethylation of chromosomal satellite repeats in HL60 human myeloid leukemia cells and thus represents a lead compound for the development of a novel class of non-nucleoside DNMT1 inhibitors. [ABSTRACT FROM AUTHOR]
Published: 2008
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Author: Rino Ragno, Silvia Simeoni, Sabrina Castellano, Caterina Vicidomini, Antonello Mai, Antonella Caroli, Anna Tramontano, Claudia Bonaccini, Patrick Trojer, Ingo Bauer, Gerald Brosch, and Gianluca Sbardella
Published: 2007
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