Search

Your search keyword '"Stassinopoulos, A"' showing total 5 results
Start Over Author "Stassinopoulos, A" Publisher american chemical society
5 results on '"Stassinopoulos, A"'

1. Induced Formation of a DNA Bulge Structure by a Molecular Wedge Ligand-Postactivated Neocarzinostatin Chromophore.

Author

Xiaolian Gao, Stassinopoulos, Adonis, Jie Ji, Youngjoo Kwon, Bare, Simona, and Goldberg, Irving H.

Subjects
*ZINOSTATIN, *DNA
Abstract

Examines the role of postactivated neocarzinostatin chromophore (NCS-chrom) in the formation of DNA bulge structure. Identification on the DNA chain cleavage properties of NCS-chrom; Occurrence of bulge-DNA sequences; Mechanisms involved in the formation of binding and cleaving species.

Published
2002
Full Text
View/download PDF

2. Probing the structure of long single-stranded DNA fragments with neocarzinostatin chromophore.

Author

Stassinopoulos, Adonis and Goldberg, Irving H.

Subjects
*NUCLEIC acids, *NUCLEIC acid probes, *CHEMICAL structure
Abstract

Presents the results of a study which characterized the base-catalyzed thiol-independent cleavage reaction of neocarzinostatin chromophore with long single-stranded DNA in order to use this reaction as a selective probe for the tertiary structure of naturally occurring ss nucleic acid. Base-catalyzed drug reaction with RNA.

Published
1995
Full Text
View/download PDF

3. Specific binding of the biradical analog of neocarzinostatin chromophore to bulged DNA:...

Author

Yang, Catherine F. and Stassinopoulos, Adonis

Subjects
*BINDING sites, *ANTINEOPLASTIC antibiotics, *SCISSION (Chemistry), *BIOCHEMICAL mechanism of action
Abstract

Investigates the specific binding of the biradical analog of the anticancer antibiotic neocarzinostatin chromophore to bulged DNA. Mechanisms for thiol-dependent cleavage; Oligodeoxynucleotides in the bulged structure; Fluorescence quenching.

Published
1995
Full Text
View/download PDF

4. Structural basis for the sequence-specific DNA strand cleavage by the enediyne Neocarzinostatin...

Author

Gao, Xiaolian and Stassinopoulos, Adonis

Subjects
*GLUTATHIONE, *DNA, *STRUCTURE-activity relationships
Abstract

Reports three-dimensional structure of glutathione post activated neocarzinostatin chromophore-DNA complex by NMR and distance geometry molecular-dynamics simulation techniques. Description of materials and methods; Results and discussion; Conclusions.

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results