Search

Your search keyword '"Tran, Duy P"' showing total 20 results
Start Over Author "Tran, Duy P" Publisher american chemical society
20 results on '"Tran, Duy P"'

18. Complementary Metal Oxide Semiconductor Compatible Silicon Nanowires-on-a-Chip: Fabrication and Preclinical Validation for the Detection of a Cancer Prognostic Protein Marker in Serum.

Author

Tran, Duy P., Wolfrum, Bernhard, Stockmann, Regina, Jing-Hong Pai, Pourhassan-Moghaddam, Mohammad, Offenhäusser, Andreas, and Thierry, Benjamin

Subjects
*NANOWIRE devices, *METAL oxide semiconductor field, *NANOCONTACTS, *NANOWIRE optical sensors, *FIELD-effect transistors
Abstract

An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (~105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

20. Toward Intraoperative Detection of Disseminated Tumor Cells in Lymph Nodes with Silicon Nanowire Field Effect Transistors.

Author

Tran DP, Winter MA, Wolfrum B, Stockmann R, Yang CT, Pourhassan-Moghaddam M, Offenhäusser A, and Thierry B

Subjects
Animals, Biosensing Techniques instrumentation, Mice, Molecular Diagnostic Techniques instrumentation, Molecular Diagnostic Techniques methods, Sensitivity and Specificity, Silicon, Biosensing Techniques methods, Lymph Nodes pathology, Nanowires chemistry, Neoplastic Cells, Circulating pathology, Transistors, Electronic
Abstract

Within an hour, as little as one disseminated tumor cell (DTC) per lymph node can be quantitatively detected using an intraoperative biosensing platform based on silicon nanowire field-effect transistors (SiNW FET). It is also demonstrated that the integrated biosensing platform is able to detect the presence of circulating tumor cells (CTCs) in the blood of colorectal cancer patients. The presence of DTCs in lymph nodes and CTCs in peripheral blood is highly significant as it is strongly associated with poor patient prognosis. The SiNW FET sensing platform out-performed in both sensitivity and rapidity not only the current standard method based on pathological examination of tissue sections but also the emerging clinical gold standard based on molecular assays. The possibility to achieve accurate and highly sensitive analysis of the presence of DTCs in the lymphatics within the surgery time frame has the potential to spare cancer patients from an unnecessary secondary surgery, leading to reduced patient morbidity, improving their psychological wellbeing and reducing time spent in hospital. This study demonstrates the potential of nanoscale field-effect technology in clinical cancer diagnostics.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results