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Start Over Author "Traquina P" Publisher american chemical society
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2. One-pot synthesis, purification, and formulation of bionanoparticle-CpG oligodeoxynucleotide hepatitis B surface antigen conjugate vaccine via tangential flow filtration.

Author

Raja K, McDonald R, Tuck S, Rodriguez R, Milley B, and Traquina P

Subjects
Hepatitis B Surface Antigens isolation & purification, Hepatitis B Vaccines chemistry, Hepatitis B Vaccines isolation & purification, Oligodeoxyribonucleotides chemical synthesis, Oligodeoxyribonucleotides isolation & purification, Vaccines, Conjugate isolation & purification, Hepatitis B Surface Antigens chemistry, Hepatitis B Vaccines chemical synthesis, Nanostructures chemistry, Oligodeoxyribonucleotides chemistry, Ultrafiltration, Vaccines, Conjugate chemistry
Abstract

The synthesis and characterization of a Hepatitis B virus vaccine (HBsIC-ISS) candidate composed of Hepatitis B surface antigen (HBsAg) bionanoparticles conjugated to multiple copies of immunostimulatory sequence oligodeoxynucleotides is presented. An efficient tangential flow filtration (TFF) method has been developed to purify the conjugated bionanoparticles from the excess conjugation reagents. The TFF technique presented can serve as a rapid and convenient alternative to current methods like ultracentrifugation for the separation of excess small molecule/polymeric conjugation reagents from chemically modified viruses and other viruslike particles.

Published
2007
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