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Your search keyword '"Xu, Guang-Yin"' showing total 4 results
Start Over Author "Xu, Guang-Yin" Publisher american chemical society
4 results on '"Xu, Guang-Yin"'

3. IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with a-Galactosylceramide as Built-in Adjuvant.

Author

Xu-Guang Yin, Xiang-Zhao Chen, Wen-Mei Sun, Xiao-Shan Geng, Xiao-Kang Zhang, Jian Wang, Pan-Pan Ji, Zhong-Yin Zhou, Dong Jae Baek, Guang-Fu Yang, Zheng Liu, and Jun Guo

Subjects
*IMMUNOGLOBULIN G, *CANCER vaccines, *GALACTOSYLCERAMIDES
Abstract

A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component vaccine STn-αGalCer is devoid of antigenic peptide, featuring the well-defined structure with high simplicity. STn-αGalCer showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes of IgG antibody were primarily IgG1 and IgG3. [ABSTRACT FROM AUTHOR]

Published
2017
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4. Preparation of Protein Conjugates via Homobifunctional Diselenoester Cross-Linker.

Author

Xu-Guang Yin, Xiao-Fei Gao, Jing-Jing Du, Xiao-Kang Zhang, Xiang-Zhao Chen, Jian Wang, Ling-Ming Xin, Ze Lei, Zheng Liu, and Jun Guo

Subjects
*PROTEIN crosslinking, *ADIPIC acid, *SMALL molecules, *HAPTENS, *DISACCHARIDES, *FLUORESCENCE
Abstract

Adipic acid diselenoester was developed as an efficient cross-linker for covalent protein conjugation with a variety of small molecular haptens, including mono- and disaccharides, peptide, fluorescence dye, and nicotine. Compared to the counterparts of N-hydroxysuccinimide (NHS) and p-nitrophenyl (PNP) linkers, the diselenoester linker demonstrates improved balance between reactivity and stability and coupling of haptens to proteins under mild conditions with high incorporation efficiency. [ABSTRACT FROM AUTHOR]

Published
2016
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