1. Mesoporous Organosilica-Based Hydrogen Sulfide Nanogenerator for Enhanced Tumor Chemotherapy.
- Author
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Xu, Jian, Zhu, Weichu, Yao, Xianxian, Mai, Shuting, Li, Chenzi, Zhang, Minghua, Shu, Dan, and Yang, Wuli
- Abstract
Conventional chemotherapy is bothered by systematic toxicity and confined therapeutic effects. Gas therapy has emerged as a potent tumor treatment, and hydrogen sulfide (H
2 S), a traditional gasotransmitter, has been found to show a tumor inhibition effect. Therefore, we established a mesoporous organosilica-based H2 S nanogenerator (MON-TPGS-DOX). Tetrasulfide bond-incorporated mesoporous organosilica nanoparticles were modified with d-α-tocopheryl polyethylene glycol succinate (TPGS), namely, MON-TPGS, and then loaded with doxorubicin (DOX) to obtain the nanogenerator. Tetrasulfide bonds in the nanogenerator could be triggered by glutathione (GSH) to release H2 S, further resulting in the degradation of nanogenerator and DOX release. GSH consumption and H2 S release led to oxidative stress in 4T1 cells, activation of apoptotic signaling cascades, and enhanced cell-killing effect. Furthermore, the nanogenerator effectively suppressed tumor growth in a tumor-bearing mice model with good biosafety, providing a promising approach for H2 S-enhanced tumor chemotherapy. [ABSTRACT FROM AUTHOR]- Published
- 2023
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