77 results on '"Zheng, Mingyue"'
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2. Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders.
3. Synthesis and Biological Evaluation of β‑Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP).
4. Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)‑one Analogues as Potent TRK Inhibitors for Cancer Treatment.
5. Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D.
6. Structure–Activity Relationship Study of 1H‑Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists.
7. Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers.
8. Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
9. Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors.
10. Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid‑β Plaques.
11. Design, Synthesis, and Bioevaluation of Pyrido[2,3‑d]pyrimidin-7-ones as Potent SOS1 Inhibitors.
12. Structure-Performance Descriptors and the Role of the Axial Oxygen Atom on M–N4–C Single-Atom Catalysts for Electrochemical CO2 Reduction.
13. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations.
14. Study of the Enzyme Activity Change due to Inkjet Printing for Biosensor Fabrication.
15. Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products.
16. Introducing Bioinspired Initiator into Resins for In Situ Repairing of 3D-Printed Metallic Structures.
17. Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism.
18. Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation.
19. Theoretical Insights into Propene Epoxidation on Au7/Anatase TiO2–x(001) Catalysts: Effect of the Interface and Reaction Atmosphere.
20. Astemizole Arrests the Proliferationof Cancer Cellsby Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex2.
21. Identifying Novel SelectiveNon-Nucleoside DNA Methyltransferase1 Inhibitors through Docking-Based Virtual Screening.
22. CatalyticMechanism of Histone Acetyltransferase p300:From the Proton Transfer to Acetylation Reaction.
23. Structure-Based Designand Synthesis of C-1-and C-4-Modified Analogs of Zanamivir as Neuraminidase Inhibitors.
24. Design, Synthesis, andPharmacological Evaluationof Monocyclic Pyrimidinones as Novel Inhibitors of PDE5.
25. Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS G12D .
26. Discovery, Optimization, and Evaluation of Novel Pyridin-2(1 H )-one Analogues as Potent TRK Inhibitors for Cancer Treatment.
27. Structure-Activity Relationship Study of 1 H -Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists.
28. Design, Synthesis, and Bioevaluation of Pyrido[2,3- d ]pyrimidin-7-ones as Potent SOS1 Inhibitors.
29. Discovery of Pyrazolo[3,4- d ]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.
30. Active Learning for Drug Design: A Case Study on the Plasma Exposure of Orally Administered Drugs.
31. Generative Models for De Novo Drug Design.
32. Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model.
33. Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
34. Discovery and Development of a Series of Pyrazolo[3,4- d ]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
35. Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
36. Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4.
37. Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study.
38. Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.
39. Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening.
40. Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.
41. Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening.
42. Correction to Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.
43. Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
44. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.
45. Mechanism of the All-α to All-β Conformational Transition of RfaH-CTD: Molecular Dynamics Simulation and Markov State Model.
46. Rapid generation of privileged substructure-based compound libraries with structural diversity and drug-likeness.
47. Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction.
48. Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: insights into multiple inhibitory mechanisms.
49. Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.
50. Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
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