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Your search keyword '"Zhou, Zhongxin"' showing total 3 results
Start Over Author "Zhou, Zhongxin" Publisher american chemical society
3 results on '"Zhou, Zhongxin"'

2. Stereospecific synthesis of bicyclic beta-lactams via metal-catalyzed carbonylative coupling and cyclization reactions

Author

Zhou, Zhongxin and Alper, Howard

Subjects
Beta lactam antibiotics -- Research, Ring formation (Chemistry) -- Research, Carbonyl compounds -- Research, Biological sciences, Chemistry
Abstract

The synthesis and characterization of bicyclic beta-lactams are described. The scheme involves the carbonylative coupling and cyclization of 2-aryl-1,3-thiazines with allyl phosphates. The reactions are catalyzed by bis(benzonitrile)palladium dichlorides and use N,N-diisopropylethylamine as a base in tetrahydrofuran. The method has been applied in the synthesis of cepham analogos, cis-7-vinyl-5-thia-1-azabicyclo(4.2.0)octan-8-ones.

Published
1996

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