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FAPESP CNPq CAPES NAP-CatSinQ Hypervalent tellurium compounds (telluranes) are promising therapeutical agents with negligible toxicities for some diseases in animal models. The C-Te bond of organotellurium compounds is commonly considered unstable, disfavoring their applicability in biological studies. In this study, the stability of a set of telluranes composed of an inorganic derivative and noncharged and charged organic derivatives was monitored in aqueous media with H-1, C-13, and Te-125 NMR spectroscopy and high-resolution mass spectrometry. Organic telluranes were found to be remarkably resistant and stable to hydrolysis, whereas the inorganic tellurane AS101 is totally converted to the hydrolysis product, trichlorooxytellurate, [TeOCl3](-), which was also observed in the hydrolysis of TeCl4. The noteworthy stability of organotelluranes in aqueous media makes them prone to further structure-activity relationship studies and to be considered for broad biological investigations. Univ São Paulo, Inst Quim, BR-05508020 São Paulo, SP, Brazil Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP, Brazil Univ Fed São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04021001 Diadema, SP, Brazil Univ Fed São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04021001 Diadema, SP, Brazil FAPESP: 2014/15962-5 FAPESP: 2015/08539-1 CNPq: 487012/2012-7 Web of Science