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Your search keyword '"Arteannuin B"' showing total 4 results
Start Over Descriptor "Arteannuin B" Publisher american chemical society (acs)
4 results on '"Arteannuin B"'

1. Asymmetric Reductive Cyclization. Total Synthesis of (−)-C10-Desmethyl Arteannuin B

Author

R. Daniel Little and Michael Schwaebe and

Subjects
Chiral auxiliary, chemistry.chemical_compound, Samarium diiodide, Stereochemistry, Chemistry, Reducing agent, Organic Chemistry, Arteannuin B, Total synthesis, Stereoselectivity, Antimalarial Agent, Desmethyl
Abstract

An efficient total synthesis of (−)-C10-desmethyl arteannuin B (5) has been achieved. The sequence features the use of a chiral auxiliary to introduce absolute asymmetry at an early stage and a stereoselective, chelation-controlled reductive cyclization of 8, using samarium diiodide as the reducing agent. The methodology promises to be applicable to the synthesis of a wide range of analogs capable of being converted to potent antimalarial agents related to artemisinin (1).

Published
1996

2. Simultaneous Determination of Artemisinin and Its Bioprecursors in Artemisia annua

Author

M. Van Montagu, Annemieke Vergauwe, Dirk Vandenberghe, and E. Van den Eeckhout

Subjects
Pharmacology, chemistry.chemical_classification, Chromatography, biology, medicine.medical_treatment, Organic Chemistry, Artemisitene, Arteannuin B, Artemisia annua, food and beverages, Pharmaceutical Science, Dihydroartemisinin, Sesquiterpene lactone, biology.organism_classification, Analytical Chemistry, Complementary and alternative medicine, chemistry, parasitic diseases, Drug Discovery, medicine, Molecular Medicine, Artemisinic acid, Artemisinin, Hplc method, medicine.drug
Abstract

Artemisia annua has been used for the treatment of fever and malaria. Artemisinin [1], a sesquiterpene lactone constituent of this plane, is responsible for its therapeutic effects. A rapid, sensitive, and specific reversed-phase hplc method using electrochemical and uv detection has been developed for the simultaneous determination in plant extracts of 1 and its bioprecursors artemisinic acid [2], arteannuin B [3], and artemisitene [4].

Published
1995

3. One-Step Stereospecific Synthesis of(-)-Arteannuin B

Author

James D. McChesney, Mankil Jung, Hala N. ElSohly, and Yongyeol Yoo

Subjects
Pharmacology, biology, Stereochemistry, Organic Chemistry, Arteannuin B, Artemisia annua, Pharmaceutical Science, One-Step, Sesquiterpene, biology.organism_classification, Analytical Chemistry, chemistry.chemical_compound, Stereospecificity, Complementary and alternative medicine, chemistry, Drug Discovery, Molecular Medicine, Organic chemistry
Published
1987

4. The isolation of sesquiterpenes from Artemisia annua

Author

Ronald J. Roth and Nancy Acton

Subjects
biology, Botany, Arteannuin B, Artemisia annua, General Chemistry, Isolation (microbiology), biology.organism_classification, Education
Abstract

Artemisia annua is a Eurasian import in North America and has been found growing in diverse parts of the United States. Procedures have been reported for the isolation of arteannuin B and of arteannuic acid.

Published
1989

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