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Your search keyword '"Charlene Fallan"' showing total 4 results
Start Over Author "Charlene Fallan" Publisher american chemical society (acs)
4 results on '"Charlene Fallan"'

1. Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK

Author

Frederick W. Goldberg, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, M. Raymond V. Finlay, Beth Williamson, Marianne Schimpl, Alexander R. Harmer, Oladipupo B. Adeyemi, Pär Nordell, Anna S. Cronin, Mercedes Vazquez-Chantada, Derek Barratt, Antonio Ramos-Montoya, Elaine B. Cadogan, and Barry R. Davies

Subjects
Organic Chemistry, Drug Discovery, Biochemistry
Published
2022

2. The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Author

Frederick W. Goldberg, M. Raymond V. Finlay, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, Gail L. Wrigley, Marianne Schimpl, Martin R. Howard, Beth Williamson, Mercedes Vazquez-Chantada, Derek G. Barratt, Barry R. Davies, Elaine B. Cadogan, Antonio Ramos-Montoya, and Emma Dean

Subjects
Drug Discovery, Molecular Medicine
Published
2019

3. Stereospecific Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Redox Synthesis of Trifluoromethyl Dihydropyranones and Mechanistic Insights

Author

Gwydion Churchill, Charlene Fallan, Christopher J. Collett, James Douglas, Louis C. Morrill, Alyn Davies, Alexandra M. Z. Slawin, Andrew D. Smith, and James E. Taylor

Subjects
Trifluoromethyl, Hydrocarbons, Fluorinated, Molecular Structure, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Substituent, Stereoisomerism, 010402 general chemistry, 01 natural sciences, Redox, Catalysis, 0104 chemical sciences, Stereocenter, chemistry.chemical_compound, Stereospecificity, chemistry, Heterocyclic Compounds, Pyrones, Reactivity (chemistry), Methane, Oxidation-Reduction, Carbene
Abstract

N-Heterocyclic carbene (NHC)-catalyzed redox asymmetric hetero-Diels–Alder reactions of α-aroyloxyaldehydes with β-trifluoromethyl enones generates synthetically useful dihydropyranones containing a stereogenic trifluoromethyl substituent in good yields (up to 81%) and excellent diastereoselectivity and enantioselectivity (up to >95:5 dr and >99% ee). The process is stereospecific, with use of either (E)- or (Z)-β-trifluoromethyl enones forming syn- or anti-dihydropyranone products, respectively. Mechanistic studies through in situ kinetic analysis of the reaction reveal key differences in reactivity between chiral NHC precursor 1 and an achiral NHC precursor.

Published
2013

4. Ytterbium-Catalyzed Conjugate Allylation of Alkylidene Malonates

Author

Hon Wai Lam, Paul Finbar Quigley, and Charlene Fallan

Subjects
Ytterbium, Organic Chemistry, Tin Compounds, chemistry.chemical_element, Alkenes, Silanes, Medicinal chemistry, Catalysis, Malonates, chemistry, Reagent, Organic chemistry, Conjugate
Abstract

Alkylidene malonates undergo efficient conjugate allylation upon treatment with allylstannanes or allylsilanes under the action of ytterbium catalysis.

Published
2011

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