18 results on '"Davies, John W."'
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2. Mapping Adverse Drug Reactions in Chemical Space
3. Use of Ligand Based Models for Protein Domains To Predict Novel Molecular Targets and Applications To Triage Affinity Chromatography Data
4. How Similar Are Similarity Searching Methods? A Principal Component Analysis of Molecular Descriptor Space
5. Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis
6. “Virtual Fragment Linking”: An Approach To Identify Potent Binders from Low Affinity Fragment Hits
7. Understanding False Positives in Reporter Gene Assays: in Silico Chemogenomics Approaches To Prioritize Cell-Based HTS Data
8. Bridging Chemical and Biological Space: “Target Fishing” Using 2D and 3D Molecular Descriptors
9. “Bayes Affinity Fingerprints” Improve Retrieval Rates in Virtual Screening and Define Orthogonal Bioactivity Space: When Are Multitarget Drugs a Feasible Concept?
10. Enrichment of High-Throughput Screening Data with Increasing Levels of Noise Using Support Vector Machines, Recursive Partitioning, and Laplacian-Modified Naive Bayesian Classifiers
11. A 3D Similarity Method for Scaffold Hopping from Known Drugs or Natural Ligands to New Chemotypes
12. Application of Machine Learning To Improve the Results of High-Throughput Docking Against the HIV-1 Protease
13. Combination of a Naive Bayes Classifier with Consensus Scoring Improves Enrichment of High-Throughput Docking Results
14. Finding More Needles in the Haystack: A Simple and Efficient Method for Improving High-Throughput Docking Results
15. Modification of 1-Substituents in the 2-Azabicyclo[2.1.1]hexane Ring System; Approaches to Potential Nicotinic Acetylcholine Receptor Ligands from 2,4-Methanoproline Derivatives
16. PDEPT: Polymer-Directed Enzyme Prodrug Therapy. 2. HPMA Copolymer-β-lactamase and HPMA Copolymer-C-Dox as a Model Combination
17. Nonpeptide Bradykinin B2 Receptor Antagonists: Conversion of Rodent-Selective Bradyzide Analogues into Potent, Orally-Active Human Bradykinin B2 Receptor Antagonists
18. The Discovery of Capsazepine, the First Competitive Antagonist of the Sensory Neuron Excitants Capsaicin and Resiniferatoxin
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