43 results on '"Denu, John M."'
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2. Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1
3. Benchmarking Quantitative Performance in Label-Free Proteomics
4. Revealing Dynamic Protein Acetylation across Subcellular Compartments
5. Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development
6. Reading the Combinatorial Histone Language
7. Quantification of SAHA-Dependent Changes in Histone Modifications Using Data-Independent Acquisition Mass Spectrometry
8. Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation
9. Metabolic Regulation of Histone Post-Translational Modifications
10. Site-Specific Reactivity of Nonenzymatic Lysine Acetylation
11. Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger
12. Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5
13. Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiae
14. Processing Mechanism and Substrate Selectivity of the Core NuA4 Histone Acetyltransferase Complex
15. SIRT3 Substrate Specificity Determined by Peptide Arrays and Machine Learning
16. Kinetic Mechanism of the Rtt109−Vps75 Histone Acetyltransferase−Chaperone Complex
17. A Combinatorial H4 Tail Library for Exploring the Histone Code
18. Mechanism-Based Inhibition of Sir2 Deacetylases by Thioacetyl-Lysine Peptide
19. Linking SIRT2 to Parkinson’s Disease
20. Catalytic Mechanism of a MYST Family Histone Acetyltransferase, by
21. Sir2 Deacetylases Exhibit Nucleophilic Participation of Acetyl-Lysine in NAD+ Cleavage
22. Nucleosome Recognition by the Piccolo NuA4 Histone Acetyltransferase Complex
23. Catalytic Mechanism of a MYST Family Histone Acetyltransferase
24. Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family,
25. SIRT1 Top 40 Hits: Use of One-Bead, One-Compound Acetyl-Peptide Libraries and Quantum Dots to Probe Deacetylase Specificity
26. Sir2 Protein Deacetylases: Evidence for Chemical Intermediates and Functions of a Conserved Histidine
27. Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases
28. Probing the Transition-State Structure of Dual-Specificity Protein Phosphatases Using a Physiological Substrate Mimic†
29. Intramolecular Dephosphorylation of ERK by MKP3
30. Probing the Function of Conserved Residues in the Serine/Threonine Phosphatase PP2Cα
31. Kinetic Mechanism of Adenine Phosphoribosyltransferase from Leishmania donovani
32. Structural Basis for the Recognition of a Bisphosphorylated MAP Kinase Peptide by Human VHR Protein Phosphatase
33. Molecular Reactions of Protein PhosphatasesInsights from Structure and Chemistry
34. Transition State Analysis and Requirement of Asp-262 General Acid/Base Catalyst for Full Activation of Dual-Specificity Phosphatase MKP3 by Extracellular Regulated Kinase
35. Kinetic Mechanism of Human Histone Acetyltransferase P/CAF
36. Kinetic Mechanism of Human Histone Acetyltransferase P/CAF
37. Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation
38. Roles of Aspartic Acid-181 and Serine-222 in Intermediate Formation and Hydrolysis of the Mammalian Protein-Tyrosine-Phosphatase PTP1
39. Transition-State Structures for the Native Dual-Specific Phosphatase VHR and D92N and S131A Mutants. Contributions to the Driving Force for Catalysis
40. Purification and Characterization of the Low Molecular Weight Protein Tyrosine Phosphatase, Stp1, from the Fission Yeast Schizosaccharomyces pombe
41. The Catalytic Role of Aspartic Acid-92 in the Human Dual-Specific Protein-Tyrosine-Phosphatase Vaccinia H1-Related
42. Intrinsic Primary, Secondary, and Solvent Kinetic Isotope Effects on the Reductive Half-Reaction of D-Amino Acid Oxidase: Evidence against a Concerted Mechanism
43. pH and kinetic isotope effects on the reductive half-reaction of D-amino acid oxidase
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