1. Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects
- Author
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Seong Ryeol Kim, Heejung Yang, Sang Hyun Sung, Jungmoo Huh, Hyun-Jeong Ko, Hyo Moon Cho, and Jae Hyoung Song
- Subjects
Magnetic Resonance Spectroscopy ,Stereochemistry ,Pharmaceutical Science ,Antiviral Agents ,Plant Roots ,01 natural sciences ,Lignans ,Analytical Chemistry ,chemistry.chemical_compound ,Drug Discovery ,Ic50 values ,Forsythia viridissima ,Forsythia ,Pharmacology ,chemistry.chemical_classification ,Lignan ,010405 organic chemistry ,Organic Chemistry ,Glycoside ,Nuclear magnetic resonance spectroscopy ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Coxsackievirus b3 ,Molecular Medicine ,Dimerization - Abstract
Six new dimeric lignans (1-6) and one new lignan glycoside (16) were isolated from Forsythia viridissima roots along with nine known lignans (7-15). Spectroscopic analyses and chemical methods were used to determine these new structures and their absolute configurations. Among these compounds, dimatairesinol (1) and viridissimaols A-E (2-6) were assigned as dimers of dibenzylbutyrolactone analogues. Furthermore, the isolated compounds were evaluated for their antiviral activities against coxsackievirus B3 (CVB3) and human rhinovirus 1B (HRV1B). In these tests, compounds 12 and 15 showed antiviral effects against CVB3 infection with IC50 values of 15.4 and 36.4 μM, respectively, while 2, 3, 8, and 9 showed activities against HRV1B with IC50 values of 45.7, 47.5, 13.0, and 43.2 μM, respectively.
- Published
- 2019
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