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Start Over Author "Huixin Yan" Publisher american chemical society (acs)
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1. An Alternative Scalable Process for the Synthesis of 4,6-Dichloropyrimidine-5-carbonitrile

Author

Liu Bo, Chongfeng Ge, Zhenping Wu, Huixin Yan, and Bin Zhang

Subjects
Normal conditions, Process safety, Process (engineering), Computer science, business.industry, Organic Chemistry, Scalability, Production (economics), Physical and Theoretical Chemistry, Process engineering, business
Abstract

A robust, safe, and scalable process for the synthesis of 4,6-dichloropyrimidine-5-carbonitrile is described. All of the intermediates in the process are storable under normal conditions. Significant process safety evaluation was undertaken in this route, and the highlights of these studies are presented. This scalable and safe synthetic strategy can be applied for multikilogram-scale production.

Published
2018
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