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Your search keyword '"Imperatore, Concetta"' showing total 9 results
Start Over Author "Imperatore, Concetta" Publisher american chemical society (acs)
9 results on '"Imperatore, Concetta"'

1. Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability

Author

Gimmelli, Roberto, primary, Persico, Marco, additional, Imperatore, Concetta, additional, Saccoccia, Fulvio, additional, Guidi, Alessandra, additional, Casertano, Marcello, additional, Luciano, Paolo, additional, Pietrantoni, Agostina, additional, Bertuccini, Lucia, additional, Paladino, Antonella, additional, Papoff, Giuliana, additional, Menna, Marialuisa, additional, Fattorusso, Caterina, additional, and Ruberti, Giovina, additional

Published
2019
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8. Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans

Author

Yue-W. Guo, Carlo Irace, Concetta Imperatore, Jia Li, Marialuisa Menna, Anna Aiello, Rita Santamaria, Paolo Luciano, Rocco Vitalone, Imperatore, Concetta, Luciano, Paolo, Aiello, Anna, Vitalone, Rocco, Irace, Carlo, Santamaria, Rita, Li, J., Guo, Y. W., and Menna, Marialuisa

Subjects
0301 basic medicine, Pharmaceutical Science, Protein tyrosine phosphatase, Biology, 01 natural sciences, Analytical Chemistry, 03 medical and health sciences, Polyketide, chemistry.chemical_compound, Drug Discovery, Animals, Urochordata, Derivatization, Nuclear Magnetic Resonance, Biomolecular, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Pharmacology, Molecular Structure, Mediterranean Region, 010405 organic chemistry, Organic Chemistry, A protein, Protein Tyrosine Phosphatase 1B, 0104 chemical sciences, 030104 developmental biology, Complementary and alternative medicine, chemistry, Biochemistry, Polyketides, Molecular Medicine, Phosphorylation, Phosphoeleganin, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.

Published
2016

9. Glycolipids from Sponges. Part 17. Clathrosides and Isoclathrosides, Unique Glycolipids from the Caribbean Sponge Agelas clathrodes

Author

Alfonso Mangoni, Valeria Costantino, Concetta Imperatore, Ernesto Fattorusso, Costantino, Valeria, Fattorusso, Ernesto, Imperatore, Concetta, and Mangoni, Alfonso

Subjects
Stereochemistry, Pharmaceutical Science, Fatty alcohol, Agelas clathrodes, Glycolipid, Analytical Chemistry, chemistry.chemical_compound, Glucoside, Sponge, Drug Discovery, Animals, Glycosides, Nuclear Magnetic Resonance, Biomolecular, Alkyl, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, Structure elucidation, Circular Dichroism, Organic Chemistry, Glycoside, biology.organism_classification, Caribbean Region, Complementary and alternative medicine, chemistry, Aldose, Agelas, Molecular Medicine, Glycolipids
Abstract

Two families of unique glycolipids, clathrosides A-C (2a-4a) and isoclathrosides A-C (5a-7a) were isolated from the Caribbean sponge Agelas clathrodes. Clathrosides and isoclathrosides are glycosides of a very-long-chain alcohol derived from fatty acids, a new class of glycolipids that appears to be characteristic of marine sponges. The six compounds differ in configuration and in the branching of alkyl chains. Stereostructures of the clathrosides were determined by NMR and CD spectroscopy, mass spectrometry, and chemical degradation. Location of the methyl branch on the proper alkyl chain required an exceptional 1-D TOCSY experiment, in which coherence was transferred through as many as 13 vicinal couplings.

Published
2005

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